| N-Boc-6-氨基-3-苄基-3-氮杂双环[3.2.1]辛烷的合成 |
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| 引用本文： | 邓鹏朋,王丽丽,黄龙江,滕大为.N-Boc-6-氨基-3-苄基-3-氮杂双环[3.2.1]辛烷的合成[J].湖北化工,2014(2):42-43,47. |
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| 作者姓名： | 邓鹏朋 王丽丽 黄龙江 滕大为 |
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| 作者单位： | 青岛科技大学化工学院,山东青岛266042 |
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| 摘 要： | 以降冰片烯-2-酰胺为原料,经霍夫曼降解、氨基保护、双键臭氧化、苄胺的还原氨化等反应合成N-Boc-6-氨基-3-苄基-3-氮杂双环3.2.1]辛烷,通过对关键步骤的优化,总收率达到55.3％.该方法简单,操作容易且收率较高.
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| 关 键 词： | N-Boc-6-氨基-3-苄基-3-氮杂双环[3 2 1]辛烷 降冰片烯 霍夫曼降解 臭氧化 |
Synthesis of N-Boc-6-amino-3-benzyl-3-azabicyclo[3.2.1]octane |
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| DENG Peng-peng,WANG Li-li,HUANG Long-jiang,TENG Da-wei.Synthesis of N-Boc-6-amino-3-benzyl-3-azabicyclo[3.2.1]octane[J].Hubei Chemical Industry,2014(2):42-43,47. |
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| Authors: | DENG Peng-peng WANG Li-li HUANG Long-jiang TENG Da-wei |
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| Affiliation: | (College of Chemical Engineering ,Qingdao University of Science and Technology, Qingdao 266042, China) |
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| Abstract: | N-Boc-6-amino-3-benzyl-3-azabicyclo-3.2. 1]octane was synthesized using bicyclo2.2, l＇]hept-5- ene-2-carboxylic acid amide as raw material by Hofmann degradation, amino-group protection, ozonation of double bond,reductive ammoniation of benzylamine. The total yield reached 55.3% through optimization of the key steps. The method is simple with easy operation and high yield. |
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| Keywords: | N-Boc-6-amino-3-benzyl-3-azabicyclo [ 3 2 1 ] octane norbornene Hofmann degradation ozona-tion |
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