| 聚乳酸/纳米四氧化三铁载阿奇霉素缓释剂的制备及性能研究 |
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| 引用本文： | 马喜峰,汤春妮,李斌.聚乳酸/纳米四氧化三铁载阿奇霉素缓释剂的制备及性能研究[J].湖北化工,2014(2):35-37. |
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| 作者姓名： | 马喜峰 汤春妮 李斌 |
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| 作者单位： | 陕西国防工业职业技术学院化学工程学院,陕西西安710302 |
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| 基金项目： | 陕西国防工业职业技术学院研究与开发项目（Gfy13-25） |
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| 摘 要： | 采用乳化-溶剂挥发法,以可生物降解材料聚乳酸为载体,在其中加入医药级阿奇霉素和一定量纳米四氧化三铁制备聚乳酸/纳米四氧化三铁载阿奇霉素缓释微球,通过正交实验优化了制备工艺,并研究了微球的释药行为.结果表明,微球具有明显的药物缓释作用.
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| 关 键 词： | 纳米四氧化三铁 聚乳酸 载药 阿奇霉素 |
Study on Preparation and Performance of PLA/Nano-Fe3O4 Loading Azithromycin Sustained Release |
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| MA Xi-feng,TANG Chun-ni,LI Bin.Study on Preparation and Performance of PLA/Nano-Fe3O4 Loading Azithromycin Sustained Release[J].Hubei Chemical Industry,2014(2):35-37. |
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| Authors: | MA Xi-feng TANG Chun-ni LI Bin |
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| Affiliation: | (School of Chemical Engineering, Shanxi Institute of Technology, X i＇an 710302 ,China) |
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| Abstract: | PLA/Nano-Fe3 O4-AZM-MS （microsphere of PLA/nano-Fe3O4 loading azithromycin） was pre- pared by emulsification-solvent evaporation method from medicinal azithromycin（AZM） and nano-Fe2o3 with biodegradable material polylactie aeid（PLA） as carrier. The preparation conditions were optimized through or- thogonal experiment. And drug release behavior of PLA/nano-Fes O4-AZM-MS was also studied. The results showed that PLA/nano-Fes O4-AZM-MS possessed obvious drug release property. |
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| Keywords: | nano-Fe3O4 polylactic acid drug loading azithromycin |
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