Altering associations of doxorubicin‐loaded alginate esters micelles in presence of β‐cyclodextrin |
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Authors: | Qiquan Zhou Jisheng Yang |
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Affiliation: | Department of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, China |
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Abstract: | The aim of this article was to evaluate the effects of β‐cyclodextrin (β‐CD) on doxorubicin (DOX)‐loaded alginate esters (SA‐C16) micelles (DOX/SA‐C16) in aqueous solution. DOX was physically loaded into SA‐C16 micelles by an o/w emulsion method with a substantial encapsulation efficiency (EE) level (36.12%), and DOX/SA‐C16 was distributed in size diameters of approximately 254 nm. SA‐C16 as carriers for the DOX can lead to the formation of associative networks in aqueous solutions between the hydrophobic tails of SA‐C16 and DOX, and the dried morphology of DOX/SA‐C16 aggregate was spherical shape. Addition of β‐CD to the system of DOX/SA‐C16 facilitated decoupling of these associations via inclusion complex formation between β‐CD cavities and the polymer hydrophobic tails that produced the release of DOX immediately, and the EE level was dropped to 0.08%, and at the same time the size distribution of aggregate was increased to about 413 nm, moreover, the aggregate was relatively large and becoming irregular spherical shape. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014 , 131, 40702. |
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Keywords: | biocompatibility biomaterials functionalization of polymers |
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