Protective effect of histidine on MPP+-induced hydroxyl radical generation in rat striatum |
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Authors: | T Obata T Inada |
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Affiliation: | Department of Pharmacology, Oita Medical University, 1-1, Hasama-machi, Oita 879-5593, Japan.tobata@oita-med.ac.jp |
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Abstract: | We investigated the efficacy of histidine on MPP+-induced hydroxyl radical (.OH) formation in extracellular fluid of rat striatum. Rats were anesthetized and sodium salicylate in Ringer's solution (0.5 nmol microl-1 min-1) was infused through a microdialysis probe to detect the generation of.OH as reflected by the nonenzymatic formation of 2,3-dihydroxybenzoic acid (DHBA) in the striatum. MPP+ (5 mM) clearly produced an increase in.OH formation. However, histidine (25 mM) reduced the.OH formation by the action of MPP+. These results indicate that histidine protects MPP+-induced.OH formation in rat striatum. |
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