搅拌生物反应器的循环时间分布和混合结构模型

利用磁粒子流动跟踪法对搅拌生物反应器的循环时间分布进行测定,并将Rushton径向流桨和两种新型轴向流桨在不同介质粘度和转速下的循环时间分布进行比较和性能评价。建立了单桨搅拌生物反应器的混合结构模型,对循环时间分布数据进行拟合,求得模型参数,进而讨论了不同实验条件下模型参数的变化。结果表明,对于非牛顿、高粘度发酵过程,轴向流桨比Rushton桨具有更好的混合特性。

CIRCULATION TIME DISTRIBUTION AND STRUCTURED MIXING MODEL OF STIRRED BIOREACTORS

The magnetic flow follower method was used to measure liquid circulation time distribution (CTD) in a stirred bioreactor. CTD was studied in water and CMC solution systems with Rushton turbine and two kinds of axial flow impeller respectively. The mixing performance of the three impellers was evaluated. A structured mixing model was developed for agitated bioreactor with a single impeller. The model parameters were evaluated by fittng the model prediction results with the experiment data of the flow follower method. The parameters under different experimental conditions were investigated and compared. The results showed that the axial impeller had better mixing performance than Rushton turbine for non -Newtonian, high viscous fermentation processes.