| 10-23脱氧核酶的研究进展 |
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| 引用本文： | 王爱民.10-23脱氧核酶的研究进展[J].粉末涂料与涂装,2011,24(3):357-361. |
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| 作者姓名： | 王爱民 |
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| 作者单位： | 上海理工大学医疗器械与食品学院生物热科学研究所; |
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| 基金项目： | 上海市教育委员会科研创新项目(09YZ230) |
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| 摘 要： | 10-23脱氧核酶(Deoxyribozyme,DRz)是利用体外分子进化技术筛选得到的一种具有催化功能的单链DNA片段,具有高效的催化活性及特异的序列识别能力,能催化RNA特定部位的切割反应,抑制相应蛋白的表达.本文就10-23 DRz的结构、活性影响因素、反应机制、生物特性及应用的研究进展作一综述.
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| 关 键 词： | 10-23脱氧核酶 生物特性 基因治疗 |
Progress in Research on 10-23 DNAzyme |
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| WANG Ai-min.Progress in Research on 10-23 DNAzyme[J].Chinese Journal of Biologicals,2011,24(3):357-361. |
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| Authors: | WANG Ai-min |
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| Affiliation: | WANG Ai-min,ZHOU Guo-yan(Institute of Thermal Science,School of Medical Instrument and Food Engineering,Shanghai University of Science and Technology,Shanghai 200093,China) |
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| Abstract: | 10-23 DNAzyme(10-23 DRz) are a set of single stranded DNA segments which derived from a combinatorial library of sequences by molecular technique in vitro.With high catalytical activity and sequence specificity against the target RNA,10-23 DRz can be designed to cleave any target RNA in a sequence specific manner,and inhibit the expression of corresponding proteins.In this paper,the progress in research on 10-23 DRz,including the structure,influencing factors of activity,mechanism,biological characters and ... |
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| Keywords: | 10-23 Deoxyribozyme Biological character Gene therapy |
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