Effects of bioactive ceramics on the pathogenesis of rat vascular smooth muscle cells treated with phorbol 12-myristate 13-acetate |
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Authors: | Tae-Sung Lee Kwan-Kyu Park Hae-Sim Cho Young-Ae Choo Meeyul Hwang |
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Affiliation: | (1) Research Institute of Biomedical Engineering, Catholic University of Daegu School of Medicine, 3056-6, Daemyung-4-Dong, Nam-gu, Daegu, 705-034, Korea;(2) Department of Obstetrics and Gynecology, Catholic University of Daegu School of Medicine, Daegu, Korea;(3) Department of Pathology, Catholic University of Daegu School of Medicine, Daegu, Korea |
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Abstract: | Vascular smooth muscle cells (VSMCs) play a pivotal role in vascular injury through proliferation and migration. Pro-inflammatory
cytokines and cyclooxygenase (COX)-2 and nitric oxide synthase (NOS) are highly associated with the pathogenesis of VSMCs.
We investigated the effect of bioactive ceramics on the expression of inflammatory cytokines, COX-2, and inducible NOS (iNOS)
induced by phorbol 12-myristate 13-acetate (PMA) in rat VSMCs. The ceramics inhibited mRNA expression of IL-1β, TNF-α, IL-6,
COX-2, and iNOS. Prostaglandin release was also diminished by the ceramics. The bioactive ceramics effect on cytokines, COX-2,
and iNOS expression was achieved by inhibition of NF-κB activity. Interestingly, the ceramics-induced up-regulation of expression
of endothelial NOS resulted in an increase of nitric oxide production. Thus, bioactive ceramics may have dual effects on the
pathogenesis of VSMCs by regulation of NF-κB activity and NO production. |
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