Insect‐Specific Production of New GameXPeptides in Photorhabdus luminescens TTO1, Widespread Natural Products in Entomopathogenic Bacteria |
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| Authors: | Friederike I Nollmann Christina Dauth Dr Geraldine Mulley Dr Carsten Kegler Marcel Kaiser Prof Dr Nick R Waterfield Prof Dr Helge B Bode |
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| Affiliation: | 1. Merck Stiftungsprofessur für Molekulare Biotechnologie, Fachbereich der Biowissenschaften, Goethe Universit?t Frankfurt, Max‐von‐Laue‐Strasse 9, 60438 Frankfurt am Main (Germany);2. School of Biological Sciences, University of Reading, Reading, RG6 6AJ (UK);3. Swiss Tropical and Public Health Institute, Parasite Chemotherapy, Socinstrasse 57, P.O. Box, 4002 Basel (Switzerland);4. Division of Microbiology and Infection, Warwick Medical School, University of Warwick, Coventry, CV4 7AL (UK);5. Buchmann Institute for Molecular Life Sciences (BMLS), Goethe Universit?t Frankfurt, Max‐von‐Laue‐Strasse 15, 60438 Frankfurt am Main (Germany) |
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| Abstract: | Discovery of new natural products by heterologous expression reaches its limits, especially when specific building blocks are missing in the heterologous host or the production medium. Here, we describe the insect‐specific production of the new GameXPeptides E–H ( 5 – 8 ) from Photorhabdus luminescens TTO1, which can be produced heterologously from expression of the GameXPeptide synthetase GxpS only upon supplementation of the production media with the missing building blocks, and thus must be regarded as the true natural products under natural conditions. |
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| Keywords: | aminophenylalanine environment‐specific natural products nonribosomal peptides Photorhabdus |
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