Using Small Molecules to Dissect Non‐apoptotic Programmed Cell Death: Necroptosis,Ferroptosis, and Pyroptosis |
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| Authors: | Ting Dong Daohong Liao Xiaohui Liu Prof. Dr. Xiaoguang Lei |
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| Affiliation: | 1. Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and, Molecular Engineering of Ministry of Education, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Synthetic and Functional Biomolecules Center and, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China;2. National Institute of Biological Sciences (NIBS), Beijing, China;3. http://www.chem.pku.edu.cn/leigroup/ |
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| Abstract: | Genetically programmed cell death is a universal and fundamental cellular process in multicellular organisms. Apoptosis and necroptosis, two common forms of programmed cell death, play vital roles in maintenance of homeostasis in metazoans. Dysfunction of the regulatory machinery of these processes can lead to carcinogenesis or autoimmune diseases. Inappropriate death of essential cells can lead to organ dysfunction or even death; ischemia–reperfusion injury and neurodegenerative disorders are examples of this. Recently, novel forms of non‐apoptotic programmed cell death have been identified. Although these forms of cell death play significant roles in both physiological and pathological conditions, the detailed molecular mechanisms underlying them are still poorly understood. Here, we discuss progress in using small molecules to dissect three forms of non‐apoptotic programmed cell death: necroptosis, ferroptosis, and pyroptosis. |
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| Keywords: | cancer ferroptosis necroptosis programmed cell death pyroptosis signal transduction |
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