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A Synthetic Transcriptional Activator of Genes Associated with the Retina in Human Dermal Fibroblasts |
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| Authors: | Junetha Syed Anandhakumar Chandran Dr. Ganesh N. Pandian Junichi Taniguchi Shinsuke Sato Kaori Hashiya Dr. Gengo Kashiwazaki Dr. Toshikazu Bando Prof. Hiroshi Sugiyama |
| Affiliation: | 1. Department of Chemistry, Graduate School of Science Kyoto University, Kitashirakawa‐oiwakecho, Sakyo‐ku, Kyoto 606‐8502 (Japan);2. Institute for Integrated Cell‐Material Sciences (WPI‐iCeMS), Kyoto University, Yoshida‐ushinomiyacho, Sakyo‐ku, Kyoto 606‐8501 (Japan) |
| Abstract: | Small molecules capable of modulating epigenetic signatures can activate the transcription of tissue‐restricted genes in a totally unrelated cell type and have potential use in epigenetic therapy. To provide an example for an initial approach, we report here on one synthetic small‐molecule compound—termed “SAHA–PIP X”—from our library of conjugates. This compound triggered histone acetylation accompanied by the transcription of retinal‐tissue‐related genes in human dermal fibroblasts (HDFs). |
| Keywords: | artificial transcription activators DNA recognition gene expression histone acetylation transcription profiling |