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Short-acquisition-time JPRESS and its application to paediatric brain tumours |
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| Authors: | Carlin Dominic Babourina-Brooks Ben Arvanitis Theodoros N Wilson Martin Peet Andrew C |
| Affiliation: | 1.Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, West Midlands, UK ;2.Birmingham Women’s and Children’s Hospital NHS Foundation Trust, Birmingham, West Midlands, UK ;3.Institute of Digital Healthcare, WMG, University of Warwick, Coventry, UK ;4.Centre for Human Brain Health, School of Psychology, University of Birmingham, Birmingham, West Midlands, UK ;5.Clinical Research Block, Institute of Child Health, Whittall Street, Birmingham, B4 6NH, UK ; |
| Abstract: | Objective To develop and assess a short-duration JPRESS protocol for detection of overlapping metabolite biomarkers and its application to paediatric brain tumours at 3 Tesla. Materials and methodsThe short-duration protocol (6 min) was optimised and compared for spectral quality to a high-resolution (38 min) JPRESS protocol in a phantom and five healthy volunteers. The 6-min JPRESS was acquired from four paediatric brain tumours and compared with short-TE PRESS. ResultsMetabolite identification between the 6- and 38-min protocols was comparable in phantom and volunteer data. For metabolites with Cramer–Rao lower bounds?>?50%, interpretation of JPRESS increased confidence in assignment of lactate, myo-Inositol and scyllo-Inositol. JPRESS also showed promise for the detection of glycine and taurine in paediatric brain tumours when compared to short-TE MRS. ConclusionA 6-min JPRESS protocol is well tolerated in paediatric brain tumour patients. Visual inspection of a 6-min JPRESS spectrum enables identification of a range of metabolite biomarkers of clinical interest. |
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