Supramolecular Analysis of Monosaccharide Derivatives Using Cucurbit[7]uril and Electrospray Ionization Tandem Mass Spectrometry |
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Authors: | Hyun Hee L Lee Prof?Dr Hugh I Kim |
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Affiliation: | Department of Chemistry, Korea University, Seoul, 02841 Republic of Korea |
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Abstract: | Identification of monosaccharide derivatives using an analytical technique is difficult due to their isomeric structures and similar physical properties. Although mass spectrometry (MS) has emerged as a prominent technique for this purpose, a comprehensive MS-based method for analyzing diverse monosaccharide species is yet to be developed. Herein, we employ host-guest chemistry using cucurbit7]uril (CB7]) with MS to identify four different monosaccharide derivative species. Tandem MS analysis distinguishes the monosaccharide derivatives based on the unique fragmentation pattern produced when forming gas-phase complexes with CB7]. The ion mobility studies combined with computational calculations reveal that subtle differences in isomers cause distinct orientations inside CB7] cavity, resulting in different fragmentation patterns of the isomers. This unique study demonstrates that host-guest chemistry combined with MS can be used for developing effective isomer analysis techniques. |
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Keywords: | carbohydrates host-guest systems mass spectrometry supramolecular chemistry |
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