Direct synthesis of [DOTA-DPhe1]-octreotide and [DOTA-DPhe1,Tyr3]-octreotide (SMT487): two conjugates for systemic delivery of radiotherapeutical nuclides to somatostatin receptor positive tumors in man |
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Authors: | R Albert P Smith-Jones B Stolz C Simeon H Knecht C Bruns J Pless |
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Affiliation: | Novartis Pharma AG, Basle, Switzerland. rainer.albert@pharma.novartis.com |
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Abstract: | Direct attachment of unprotected DOTA (1,4,7,10-tetraazacyclododecane-N',N",N"',N"-tetraacetic acid) to partially suitably protected octreotide or Tyr3]-octreotide leads after deprotection to DOTA-DPhe1]-octreotide (III) and DOTA-DPhe1,Tyr3]-octreotide (IV). These DOTA-containing somatostatin analogs, when labeled with a radiotherapeutic nuclide, are useful as antitumor agents. The partially protected peptides are accessible via solid phase peptide synthesis (SPPS) followed by selective cleavage under mild acidic conditions from the resin. |
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