| 单烷氧取代苯基哌嗪类盐酸盐的合成 |
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| 引用本文： | 白宝清,袁牧,肖志会,周鸿,周欣.单烷氧取代苯基哌嗪类盐酸盐的合成[J].精细化工,2004,21(6):468-469,473. |
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| 作者姓名： | 白宝清 袁牧 肖志会 周鸿 周欣 |
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| 作者单位： | 1. 贵州省、中国科学院天然产物化学重点实验室,贵州,贵阳,550002;贵州大学,精细化工研究中心,贵州,贵阳,550025
2. 贵州省、中国科学院天然产物化学重点实验室,贵州,贵阳,550002 |
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| 基金项目： | 国家自然科学基金(30060087)~~ |
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| 摘 要： | 单烷氧基取代苯基哌嗪盐酸盐是合成苯基哌嗪类药物的重要中间体。以二乙醇胺为起始原料,经氯代反应制得β,β1 二氯代二乙基胺盐酸盐,然后与单烷氧基取代苯胺经环合反应合成5个目标化合物。其结构经红外光谱、核磁共振氢谱、质谱证实与目标化合物的结构一致。
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| 关 键 词： | 二乙醇胺 烷氧基苯胺 苯基哌嗪 |
| 文章编号： | 1003-5214(2004)06-0468-03 |
Synthesis of Monoalkoxysubstituted Phenylpiperazine Hydrochlorides |
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| BAI Bao-qing.Synthesis of Monoalkoxysubstituted Phenylpiperazine Hydrochlorides[J].Fine Chemicals,2004,21(6):468-469,473. |
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| Authors: | BAI Bao-qing |
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| Affiliation: | BAI Bao-qing~ |
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| Abstract: | Monoalkoxysubstituted phenylpiperazine hydrochlorides are important intermediates of substituted phenylpiperazine drugs.The starting material diethanolamine was halogenated to give β,β~1-dihalogenated diethylamine hydrochloride,which then reacted separately with five monoalkoxysubstituted anilines to afford the corresponding monoalkoxysubstituted phenylpiperazine hydrochlorides.The synthesized compounds were identified by ~1HNMR,IR and MS.The results are consistent with the proposed structures. |
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| Keywords: | diethanolamine alkoxyaniline phenylpiperazines |
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