基于近红外光谱的脑血氧无创监测系统研究

目前临床使用的脑血氧无创监测设备大多为双波长，由于黑色素的吸收会导致测量结果出现偏差，因此需要对测量结果进行修正。为此本文基于近红外光谱无创监测脑血氧的基本原理，针对现有脑血氧无创监测设备的不足，考虑前额叶的光学特性，研制了一种四波长探测光源(700、760、805、850 nm)以及双路光电检测器的脑血氧无创监测传感装置，并建立了光谱吸光度的数学模型，在此基础上构建了新型的脑血氧无创监测系统，实现了可抑制皮肤黑色素成分干扰的脑血氧信息无创测量。最后通过对Valsalva运动以及空载的对照实验进行秩和分析，初步验证了本系统的有效性。

Research on non-invasive monitoring system based on cerebralblood oxygen on near infrared spectroscopy

At present, most of the non-invasive monitoring equipment for cerebral blood oxygen in clinical use is dual-wavelength.Because the absorption of melanin will cause deviations in the measurement results, the measurement results need to be corrected. Forthis reason, based on the basic principle of non-invasive monitoring of cerebral blood oxygen by near infrared spectroscopy, in view of theshortcomings of existing non-invasive monitoring equipment for cerebral blood oxygen, considering the optical characteristics of theprefrontal lobe, a four-wavelength detection light source (700, 760, 805, 850 nm) and a dual-channel photoelectric detector for noninvasive monitoring of cerebral blood oxygen, and a mathematical model of spectral absorbance is established. On this basis, a new typeof non-invasive monitoring system for cerebral blood oxygen is constructed, which can inhibit the interference of skin melanin componentsto non-invasively measure the cerebral blood oxygen information. Finally, through the rank sum analysis of the Valsalva exercise and noload control experiments, the effectiveness of the system is preliminarily verified.