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| 表面肝素改性TLM钛合金的血液相容性评价 | |
| 引用本文： | 余 森,于振涛,王 贵,Matthew S. Dargusch,张明华. 表面肝素改性TLM钛合金的血液相容性评价[J]. 稀有金属材料与工程, 2009, 38(3): 384-388 |
| 作者姓名： | 余 森 于振涛 王 贵 Matthew S. Dargusch 张明华 |
| 作者单位： | 1. 西北有色金属研究院,陕西,西安,710016 2. CAST CRC,昆士兰大学工程学院,布里斯班,澳人利亚,4072 3. 第四军医大学唐都医院全军骨肿瘤研究所,陕西,西安,710038 |
| 基金项目： | Key Foundation Research Project of China，国家自然科学基金 |
| 摘 要： | 在新型近β钛合金TLM(Ti-3Zr2Sn-3Mo-25Nb)表面用溶胶-凝胶法镀上一层TiO2薄膜,再将薄膜依次用羟基化溶液和胺基化溶液处理以在薄膜表面引入活性OH-和NH2-,然后通过该活性官能团将肝素共价键接在薄膜表面.利用XRD、SEM和EDS研究了TiO2薄膜的相结构和表面特性:通过测定材料表面的接触角、溶血率和血小板黏附行为对肝素化TLM合金的血液相容性进行分析、评价.结果表明,表面肝素化处理后TLM合金的血液相容性得到了明显的改善. |
| 关 键 词： | 血液相容性 肝素化 TLM合金 薄膜 表面改性 |
| 收稿时间： | 2008-03-25 |
Evaluation of Haemocompatibility of TLM Titanium Alloy with Surface Heparinization |
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| Yu Sen,Yu Zhentao,Wang Gui,Matthew S. Dargusch and Zhang Minghua. Evaluation of Haemocompatibility of TLM Titanium Alloy with Surface Heparinization[J]. Rare Metal Materials and Engineering, 2009, 38(3): 384-388 | |
| Authors: | Yu Sen Yu Zhentao Wang Gui Matthew S. Dargusch Zhang Minghua |
| Abstract: | A layer of TiO2 film was prepared by sol-gel method on the surface of TLM(Ti-3Zr-2Sn-3Mo-25Nb) alloy. Then the coated samples were treated by hydroxyl solution and amination solution in order to introduce the OH- and NH2- active groups, and the heparin was linked on the surface of TiO2 film through these active groups. The phase identification and the surface characteris-tics of the samples were successively undertaken using XRD, SEM and EDS. The in vitro blood compatibility of the TLM alloy specimens with ... |
| Keywords: | haemocompatibility heparinization TLM alloy film surface modification |
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