| 雷洛昔芬中间体4-甲氧基-α-[(3-甲氧基苯基)硫代]苯乙酮含量的反相高效液相色谱测定 |
| |
| 引用本文： | 张艳林,胡德禹,宋宝安,卢平,杨松,樊玲娥,刘平生,薛伟.雷洛昔芬中间体4-甲氧基-α-[(3-甲氧基苯基)硫代]苯乙酮含量的反相高效液相色谱测定[J].精细化工中间体,2006,36(6):65-67. |
| |
| 作者姓名： | 张艳林 胡德禹 宋宝安 卢平 杨松 樊玲娥 刘平生 薛伟 |
| |
| 作者单位： | 贵州大学,精细化工研究开发中心,贵州,贵阳,550025;绿色农药与生物工程教育部重点实验室,贵州,贵阳,550025 |
| |
| 基金项目： | 贵州省省长基金项目(2005374) |
| |
| 摘 要： | 采用反相高效液相色谱法,以v(甲醇)v∶(水)=802∶0作为流动相,用C18柱和二极管阵列检测器(DAD,282nm),测定4-甲氧基--α(3-甲氧基苯基)硫代]苯乙酮的含量。结果表明,4-甲氧基--α(3-甲氧基苯基)硫代]苯乙酮在0.02～0.90μg内呈良好的线性关系,r=0.99999。该方法灵敏、快速、准确,可用于4-甲氧基--α(3-甲氧基苯基)硫代]苯乙酮含量的测定。
|
| 关 键 词： | 4-甲氧基-α-[(3-甲氧基苯基)硫代]苯乙酮 检测 高效液相色谱 |
| 文章编号： | 1009-9212(2006)06-0065-03 |
| 收稿时间： | 2006-10-23 |
| 修稿时间： | 2006年10月23 |
Determination of Content of Raloxifen Intermediate 4-Methoxy-α-[(3-methoxyphenyl)thio]Acetophenone by R-HPLC |
| |
| ZHANG Yan-lin,HU De-yu,SONG Bao-an,LU ping,YANG Song,FAN Ling-e,LIU Ping-sheng,XUE Wei.Determination of Content of Raloxifen Intermediate 4-Methoxy-α-[(3-methoxyphenyl)thio]Acetophenone by R-HPLC[J].Fine Chemical Intermediates,2006,36(6):65-67. |
| |
| Authors: | ZHANG Yan-lin HU De-yu SONG Bao-an LU ping YANG Song FAN Ling-e LIU Ping-sheng XUE Wei |
| |
| Affiliation: | 1. Center for Research and Development of Fine Chemicals, Guiyang 550025, China; 2. Key Laboratory of Green Pesticide and Bioengineering, Ministry of Education, GuiZhou University, Guiyang 550025, China |
| |
| Abstract: | A quantitative analytical method of 4-Methoxy-α-(3-Methoxyphenyl)thio] acetophenone by R-HPLC was described,using v(methanol) ∶ v(water) = 80 ∶ 20 as mobile phase,using Kromasil C18 column at DAD detector(282 nm).Result showed that 4-methoxy-α-(3-methoxyphenyl)thio] acetophenone was linear(r = 0.999 99)and had a good linear correlation in the range of 0.02~0.90 μg,This suggested that the method was proved to be sensitive,fast and accurate,and could be used for determining the content of 4-methoxy-α-(3-methoxyphenyl)thio] acetophenone. |
| |
| Keywords: | 4-methoxy-α-[(3-methoxyphenyl)thio]acetophenone determination HPLC |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
