Effect of microstructure on blood cell clogging in blood separators based on capillary action |
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Authors: | Duckjong Kim Jae Young Yun Sang-Jin Park Seung S. Lee |
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Affiliation: | (1) Micro/Bio Fluidics Team, Korea Institute of Machinery and Materials, 305-343 Daejeon, South Korea;(2) Department of Mechanical Engineering, Korea Advanced Institute of Science and Technology, 305-701 Daejeon, South Korea |
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Abstract: | In this study, the blood cell clogging phenomenon occurring in blood separators based on capillary action is carefully investigated and how to minimize the reduction in plasma separation speed caused by clogging is discussed. Four different blood separators are fabricated on optically transparent glass substrates to clearly observe the blood plasma separation and the blood cell clogging in the microfluidic devices. Each separation experiment is captured by a high-speed video camera. The captured images are analyzed using a theoretical model proposed in this study to quantify the effect of the microstructure on the degree of blood cell clogging. Finally, design guidelines for the microstructure of the micro blood separator are discussed based on the analysis. D. Kim and J. Y. Yun contributed equally to this work. |
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