Antagonist for atrial natriuretic peptide receptors ameliorates glomerular hyperfiltration in diabetic rats |
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Authors: | R Kikkawa M Haneda K Sakamoto D Koya T Shikano S Nakanishi Y Matsuda Y Shigeta |
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Affiliation: | Third Department of Medicine, Shiga University of Medical Science, Japan. |
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Abstract: | To evaluate the possible contribution of atrial natriuretic peptide (ANP) to the development of glomerular hyperfiltration, we examined the effect of non-peptide competitive antagonist for biological receptors of ANP, HS-142-1, on glomerular filtration rate (GFR) and renal plasma flow (RPF) in diabetic rats. Increased GFR and RPF in diabetic rats were significantly ameliorated by the injection of HS-142-1, while blood pressure remained unchanged. Urinary cyclic GMP excretion was significantly higher in diabetic rats than in control rats and HS-142-1 decreased urinary cGMP excretion significantly. These results indicate that atrial natriuretic peptide contributes to the development of glomerular hyperfiltration and hyperperfusion in diabetes and HS-142-1 might be useful in the treatment of them. |
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