Inertial microfluidics for continuous particle filtration and extraction |
| |
Authors: | Ali Asgar S Bhagat Sathyakumar S Kuntaegowdanahalli Ian Papautsky |
| |
Affiliation: | (1) Department of Electrical and Computer Engineering, University of Cincinnati, 814 Rhodes Hall, ML030, Cincinnati, OH 45040, USA |
| |
Abstract: | In this paper, we describe a simple passive microfluidic device with rectangular microchannel geometry for continuous particle
filtration. The design takes advantage of preferential migration of particles in rectangular microchannels based on shear-induced
inertial lift forces. These dominant inertial forces cause particles to move laterally and occupy equilibrium positions along
the longer vertical microchannel walls. Using this principle, we demonstrate extraction of 590 nm particles from a mixture
of 1.9 μm and 590 nm particles in a straight microfluidic channel with rectangular cross-section. Based on the theoretical
analysis and experimental data, we describe conditions required for predicting the onset of particle equilibration in square
and rectangular microchannels. The microfluidic channel design has a simple planar structure and can be easily integrated
with on-chip microfluidic components for filtration and extraction of wide range of particle sizes. The ability to continuously
and differentially equilibrate particles of different size without external forces in microchannels is expected to have numerous
applications in filtration, cytometry, and bioseparations. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|