Thermogravimetric characterization of chitosan/alginate microparticles loaded with different drugs |
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| Authors: | M I Popa Gabriela Lisa N Aelenei |
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| Affiliation: | (1) Chemical Engineering and Environmental Protection Faculty, Chemical Engineering Department, Gh. Asachi Technical University of Iasi, 700050 Iasi, Romania |
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| Abstract: | Summary The thermal behavior of several chitosan/alginate /drug microparticle formulations containing ciprofloxacin,
ibuprofen, ketoprofen or tannic acid was investigated by thermogravimetry in inert atmosphere in the temperature
range of 25 – 900oC. The chemical composition and the method used for
drug incorporation influenced the thermal stability of the products. It was found that the entrapment
of the drug in chitosan, alginate or chitosan/alginate complex modifies the degradation mechanism introducing
new degradation steps by comparison with raw polymers. The activation energy for the main degradation
step is also changed. |
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| Keywords: | chitosan alginate microsphere thermogravimetry chitosan/alginate/drug ciprofloxacin ketoprofen ibuprofen tannic acid |
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