The involvement of calpain-dependent proteolysis of the tumor suppressor NF2 (merlin) in schwannomas and meningiomas |
| |
Authors: | Y Kimura H Koga N Araki N Mugita N Fujita H Takeshima T Nishi T Yamashima TC Saido T Yamasaki K Moritake H Saya M Nakao |
| |
Affiliation: | Department of Tumor Genetics and Biology, Kumamoto University School of Medicine, Honjo, Japan. |
| |
Abstract: | Neurofibromatosis type 2 (NF2) protein, also known as merlin or schwannomin, is a tumor suppressor, and NF2 is mutated in most schwannomas and meningiomas. Although these tumors are dependent on NF2, some lack detectable NF2 mutations, which indicates that alternative mechanisms exist for inactivating merlin. Here, we demonstrate cleavage of merlin by the ubiquitous protease calpain and considerable activation of the calpain system resulting in the loss of merlin expression in these tumors. Increased proteolysis of merlin by calpain in some schwannomas and meningiomas exemplifies tumorigenesis linked to the calpain-mediated proteolytic pathway. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|