Synthesis and Biological Activity of 8-Hydroxyquinoline and 2-Hydroxypyridine Quaternary Ammonium Salts |
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| Authors: | Sahar M. Ahmed Dina A. Ismail |
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| Affiliation: | (1) Petrochemicals Department, Egyptian Petroleum Research Institute, Cairo, Egypt |
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| Abstract: | Two series of quaternary cationic surfactant were synthesized by reaction of 8-hydroxyquinoline and 2-hydroxypyridine with long chain alkyl halides (dodecyl, tetradecyl- and hexadecyl-bromide). Surface tension was measured in aqueous solution for different concentrations at 25 °C. Various surface properties of the synthesized surfactants were evaluated, particularly critical micelle concentration (CMC), efficiency (ΠCMC) as well as maximum surface excess (Γmax) and minimum surface area (A min). Micellization and adsorption in liquid/air interfaces thermodynamics were investigated. The synthesized cationic surfactants were evaluated for their biocidal activity. All compounds prepared showed good antibacterial and antifungal activities. |
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| Keywords: | Quaternary ammonium salts 8-Hydroxyquinoline 2-Hydroxypyridine Surface properties Biological activity |
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