缓释醋酸亮丙瑞林微球对大鼠子宫异位内膜的抑制作用

目的 观察国内研制的醋酸亮丙瑞林(LE)微球对异位子宫内膜的抑制作用, 并与进口醋酸亮丙瑞林微球(enanton)及醋酸亮丙瑞林(LE)注射溶液进行疗效比较。方法 以手术方法制备大鼠子宫内膜异位症模型, 将动物分为辅料组、原料药组(LE, 20 μg ·kg^-1 ·d^-1×28 d, sc)、进口微球组(enanton 20 μg ·kg^-1 ·d^-1, sc)、国产微球组(国产LE 微球2、20、200 μg·kg^-1·d^-1, sc)。结果 辅料组异位内膜体积呈增长趋势, 阳性对照药LE 20 μg·kg^-1(sc×28 d)、enanton 20 μg·kg^-1·d^-1, 及国产LE 微球2、20、200 μg·kg^-1·d^-1对异位内膜均有明显抑制作用, 且后者具有一定的剂量相关性。结论 国产醋酸亮丙瑞林微球20 μg·kg^-1·d^-1 对大鼠异位内膜的抑制作用与相同剂量的进口同类产品及原料药的作用相当。

Inhibitory effect of domestic leuprorelin acetate microspheres on experimentally induced endometriosis in rats

Aim To study the effect of leuprorelin acetate microspheres (LE-ms)on endometriosis in rats, and compare the efficacy of material drug (LE), domestic and imported LE-ms (enanton).Methods Endomet riosis was induced by endomet rial implant in rats.Then the animals were treated with LE (20 μg· kg^-1·d^-1×28 d, sc), enanton(20 μg·kg^-1·d^-1, sc) and domestic LE-ms (2, 20, 200 μg·kg^-1·d^-1, sc). Results Implants in control group continued to grow, while those in groups treated with drugs shrinked signif icantly, and domestic LE-ms could produce dose-dependent inhibitory effect on the growth of endometrial implant in rats.Conclusion The domestic LE-ms at the single dose of 20 μg·kg^-1·d^-1 has the same effectiveness as enanton and routine injection with the same does of LE for 28 days.