丹参注射液对大鼠急性心肌缺血及血液流变学的影响

目的: 观察丹参注射液对大鼠急性心肌缺血模型及急性血淤模型的影响。方法: 以垂体后叶素制备大鼠急性心肌缺血模型, 以大剂量肾上腺素配合冰浴制备大鼠急性血淤模型, 观察丹参用药对急性心肌缺血模型大鼠心电图 J点和 T 波及急性血淤模型大鼠血液流变学的影响。结果: 丹参注射液中(4.0 g·kg^-1 )、高(8.0 g·kg^-1 )剂量均明显对抗急性心肌缺血心电图J 点和 T 波的升高(P <0.05或 P <0.01), 丹参各剂量组能明显预防急性血淤模型高、 中、低切变率的血粘度及红细胞压积的升高(P <0.05或 P <0.01)。结论: 丹参可有效降低血液粘度,并具改善冠脉循环,保护缺血心肌的作用。

Effects of salvia miltiorrhiza injection on acute myocardial ischemia and hemorheology models of rat

AIM: To investigate effects of salvia mil-tiorrhiza injection on acute myocardial ischemia and hemorheology. METHODS: The acute myocardial is-chemia model and blood stasis model were established with high-dose adrenaline subcutaneous injection and be-ing socked in ice-water. The effect of salvia miltiorrhiza injection on the electrocardiogram J-point and T-ware of acute myocardial ischemia and the hemorheology of rat blood stasis model were observed. RESULTS: As com-pared with model groups, middle and high dose groups of salvia miltiorrhiza injection could obviously inhibit the rising of J-point and T-wave of the ischemic electrocardio-gram, all dose groups of salviamiltiorrhiza injection could prevent the ascending of blood viscosity and fibrinogen and hematocrit. CONCLUSION: salvia miltiorrhiza in-jection can effectively decrease blood viscosity and im-prove circulatation of coronary artery, and protect is-chemic myocardium.