不同剂量valsartan应用对SHR血压和左室心肌肥厚的影响

目的 评价不同剂量AT₁受体拮抗剂valsartan 对SHR 的降压疗效及其逆转心肌肥厚作用的影响。方法 18 只14 周龄雄性SHR 随机分成空白对照组、小剂量valsartan 组、大剂量valsartan 组, 另设WKY 正常对照组, 分别给予生理盐水、valsartan 8mg·kg^-1、valsartan 24 mg ·kg^-1, 每日1 次灌胃给药, 持续8 wk 。结果 药物干预各组SHR 动脉收缩压(SBP)水平明显下降, 尤以大剂量valsartan 组SBP 下降最显著;药物干预各组LVM/BW、TDM均明显减低。结论 不同剂量AT₁ 拮抗剂均有明显的降低SHR 的SBP 作用, 能明显抑制左室肥厚进展;大剂量用药效果最为显著。

Effect of different doses of valsartan on blood pressure and left ventricular hypertrophy in spontaneously hypertensive rats

Aim To evaluate the effects of different doses of valsartan on blood pressure and left ventricular hypertrophy in spontaneously hypertensive rats (SHR). Methods Eighteen SHR (fourteen-week-old, male) were divided into three groups (six rats in each group): SHR control group in which the rats were fed with normal saline; low dose valsartan group in which the rats were fed with valsartan 8 mg·kg^-1·d^-1 and high dose valsartan group in which the rats were fed with valsartan 24 mg·kg^-1·d^-1、all for 8 weeks. The rats in the WKY control group (n=6) were fed with normal saline for 8 weeks. Results SBP, LVM/ BW and TDM of SHR were remarkably lower than those of the control after drug intervention and the effect on SBP LV M/ BW and TDM was most remarkable in the high dose valsartan group. Conclusion Different doses of valsartan can decrease SBP of SHR and inhibit the progression of ventricular hypertrophy.