高血压病患者左室肥厚与高胰岛素血症关系的研究1

目的: 探讨高血压病患者左室肥厚与空腹胰岛素的关系。方法: 测定 83例未治疗高血压病人空腹血清胰岛素、血糖、血酯、肌酐、尿素氮等代谢水平;用心脏超声测定并计算其左室重量和左室重量指数(LVMI) 并按 LVMI 分为左室肥厚组(LVH) 和左室正常组。 结果: LVH 组的空腹血甘油三酯(TG) 和胰岛素(FIN) 分别高于左室正常组, 而胰岛素敏感指数则低于左室正常组。 多因素逐步回归分析仅显示空腹胰岛素与左室肥厚有明显正相关(r=0.49, P<0.01)。 结论: 高血压病人的高胰岛素血症与左室肥厚有密切相关, 高胰岛素血症可能参与高血压病人左室肥厚的发生和发展。

Relationship between left ventricular hypertrophy (LVH) and hyperinsuli-naemia in patients with primary hypertension1

AIM: To evluate the relation of LVH to the fasting insulin in untreated primary hypertensive pa-tients.METHODS: 83 cases of newly diagnosis and un-treated hypertensive patientswere divided into two groups (LVH group and LV normal group) according to the left ventricular mass index (LVMI) which was measured and calculated by echocardiography.The fasting insulin, lipids, glucose, creatine and urine nitrogen were assayed and compared between two groups.RESULTS: The lev-els of fasting triglyceride and insulin in LVH group were higher than LV normal group while the insulin sensitivity index was lower than the latter.The multifactor regression analysis showed that only insulin was positively correlated to LVH in primary hypertensive patients (r=0.49, P < 0.01).CONCLUSION: That hyperinsulinemia is close-ly correlated with and involvement in the pathogenesis of left ventricular hypertrophy in patients with primary hy-pertension.