卡托普利与氯沙坦合用对冠心病患者血液细胞因子的影响

目的: 探讨卡托普利与氯沙坦合用对冠心病人可溶性细胞间粘附分子-1(sICAM-1)、可溶性血管细胞粘附分子-1(sVCAM-1)、肿瘤坏死因子-α(TNF-α) 和转化生长因子β(TGF-β) 的影响。方法: 用酶联免疫吸附法和放免法测定冠心病患者治疗前后sICAM-1、sVCAM-1、TNF-α和TGF-β 的变化。结果: 在常规治疗基础上应用卡托普利和氯沙坦的病人在临床症状改善的同时, sICAM-1、TNF-α明显降低, 与常规治疗组相比, 差异具有显著性;sVCAM-1 有降低趋势, 但差异无显著性, TGF-β 水平则不同程度的升高。结论: 卡托普利与氯沙坦合用对粘附分子和细胞因子有一定的调节作用。

Combination effect of captopril and losartan on cell adhesion molecules and cytokines in the patients with coronary heart disease

AIM: To explore the effect of the combination of captopril and losartan on the sICAM-1, sVCAM-1, TNF-α, and TGF-β in the patients with coronary heart disease.METHODS: sICAM-1, sVCAM-1 and TGF-β were measured with ELISA, and TNF-αwas measured with RIA in the patients with or without the treatment of captopril and losartan.RESULTS: sICAM-1 and TNF-α decreased, and TGF-β increased distinctly in the patients given a combination of captopril and losartan compared with patients without the drugs.sVCAM-1 had the tendency of decrease in combined therapy, but no significant difference showed compared with the control patients. .CONCLUSION: The combination of captopril and losartan has the effects on the cell adhesion molecules and cytokins in patients with coronary heart disease.