阿司匹林、维拉帕米单用和合用对大鼠肠系膜微循环的影响1

目的 研究阿司匹林(Asp)与维拉帕米(Ver)合用对大鼠肠系膜微循环的影响。方法 右旋糖酐(Mr 480 000)360 mg·kg^-1 iv 制备大鼠肠系膜急性微循环障碍(AMD)模型, 采用活体微循环法观察肠系膜微循环细动, 静脉血流速度(ABFV、VBFV), 血流状态(BFS), 血管口径(AD、VD)的变化。结果 Asp 2.5、5 mg·kg^-1、Ver 0.3、0.6 mg·kg^-1,Asp+Ver(1+0.15)、(2.5 +0.3)mg·kg^-1 iv 可使ABFV 增大各为11.1 %、31.3 %、18.7 %、19.5 %、26.5 %、37.3 %; VBFV 则为12.5%、25.7 %、12.5 %、13.7 %、30%、34.7 %, BFS 改善;AD 增大4.3 %、17.9 %、31.5 %、35 %、20 %、38.1 %;VD 则为2.2%、4.2 %、25 %、31.5 %、5.8 %、23.5 %;CN 增多;Asp+Ver 可明显逆转AMD 。结论 Asp 增快ABFV、VBFV 作用优于Ver, 而Ve r 扩张AD、V D 作用强于Asp, 两者合用呈协同效应, 并对右旋糖酐诱导的AMD 具有拮抗作用。

Effects of aspirin and verapamil alone or in combination on mesenteric microcirculation of rats1

Aim To study the effects of aspirin (Asp) and verapamil (Ver) alone or in combination on mesenteric microcirculation of rats. Methods Acute microcirculation disturbance (AMD) was produced by highmolecular weight dextran (Mr 480,000) 360 mg·kg^-1 iv. A rteriol and venul blood flow velocity and diameter (ABFV, VBFV, AD, VD) and blood flow state (BFS) were observed by intravital microcirculation method. Results Asp 2.5, 5 mg °kg、Ver 0.3,0.6 mg·kg、Asp+ Ver (1+0.15),（2.5+0.3) mg·kg^-1 iv significant increase ABFV by 11.1 %, 31.3%, 18.7%,19.5%,26.5%,37.3%, VBFV by 12.5%,5.7%, 2.5%,3.7%,30%, 34.7%, AD by 4.3%, 17.9%, 31.5%, 35%, 20%, 38.1% and VD by 2.2%, 4.2%, 25%, 31.5%, 5.8%, 23.5% espectively, and got a raise in the number of capillaries and a marked improvement of BFS. Asp+ Ver(1+0.15, 2.5+0.3) mg·kg^-1 iv could reverse AMD. Conclusion Asp is superior to Ver in the increase of BFV, but Ver is superior to Asp in expansion of blood vessel. Asp in combination with Ver produces marked synergistic action and protection againist AMD