甲基强地松龙局部浸润对脊神经根炎性损伤后影响的实验研究

目的 观察甲基强地松龙局部浸润对炎性损伤脊神经根的恢复情况,探讨甲基强地松龙对非压迫状态下脊神经根损伤的保护作用。方法 20只家兔全部制成脊神经根炎性损伤的动物模型并饲养3 d分组给予甲基强地松龙或等量生理盐水局部浸润脊神经根。术后1 w k测量脊神经根的传导速度,光镜下观察脊神经根的组织学变化及脊髓后角P物质免疫组织化学染色（S-P法）。结果 甲基强地松龙组脊神经根传导速度明显恢复。组织学观察显示脊神经根间质充血、水肿程度显著减轻,范围显著缩小,炎性细胞浸润减少。脊髓灰质后角P物质免疫反应阳性纤維面积及灰度均明显小于对照组。结论 甲基强地松龙局部浸润可以降低脊神经根炎症反应、阻断疼痛传递、促进脊神经根功能恢复。

Experimental study of protective effect of local infiltration of methylpred-nisolone on injured spinal nerve root

Aim To observe the effect of infiltration of Methylprednisolone on injured spinal nerve root and the protective function of Methylprednisolone to non-impressed spinal nerve root lesion. Methods The spinal nerve roots were injured in 20 rabbits.Three days later local Methylprednisolone infiltration of spinal nerve root profromed in rabbits in experiment group? while rabbits in the control roup received equal amount of 0 9% natiiichloridi instead. The conduct velocity of spinal nerve root was measured one week after operation. The histological change of spinal nerve root and immunohistochemical stain of posterior horn of spine were observed by microscope. Results The conduct velocity was recovered obviously in experiment group. In observation of spinal nerve we found the edema and hyperaemia of matrix were impaired obviously, the lesion focus was minimized, the amount of inflammatory cells was decreased. The area of substance P positive fiber and its terminus in posterior of spinal was smaller in experiment group remarkably than in control group. Conclusions The local infiltration of Methylprednisolone can relieve inflammation inhibit the transmission of pain and accelerate recovery of spinal nerve root