盐酸丁咯地尔注射液治疗糖尿病性周围神经病变的疗效评价

目的: 观察盐酸丁咯地尔注射液治疗糖尿病性周围神经病变的疗效。方法: 糖尿病性周围神经病变患者56 例, 随机分为两组。丁咯地尔组( n = 28): 盐酸丁咯地尔150 mg 加入生理盐水250 ml, 静脉滴注, 每日1 次。常规治疗组( n =28): 采用常规治疗。两组用药持续15 d, 然后评价疗效和神经传导速度。结果: 丁咯地尔组症状明显改善, 总有效率为96. 5 %, 常规治疗组总有效率为57. 1 %, 两组差异具有显著性( P <0. 05), 并且盐酸丁咯地尔组神经传导速度明显提高( P <0. 01) 。结论: 盐酸丁咯地尔治疗糖尿病性周围神经病变疗效确切, 值得推广。

Clinical evaluation of the efficiency of buflomedil hydrochloride injection in the treatment of the damage of peripheral nerve induced by diabetes

AIM: To evaluate the efficiency of buflomedil hydrochloride injection ( Buf ) in the treatment of the damage of peripheral nerve induced by diabetes (DPN). METHODS: 28 patients with DPN were given Buf ( 150 mg·d^-1, iv gtt) and another 28 patients were used routine therapy. The treatments lasted for 15 d. RESULTS: The total efficiency rate was 96. 5 % in Buf group, while it was 57. 1 % in routine therapy group ( P <0. 01). The conduction speed of nerve in buf group was greatly improved in comparison with the routine therapy ( P <0. 01). CONCLUSION: It is reliable for Buf to treat the damage of peripheral nerve induced by diabetes.