川芎嗪的鼻腔吸收及冰片的促进作用

目的 探讨川芎嗪的鼻腔吸收及冰片的促进作用。 方法 采用大鼠在体鼻腔重循环法, 研究川芎嗪鼻腔吸收的量效关系及冰片对其鼻腔吸收的影响。 结果 循环液中川芎嗪的浓度在0.25, 0.75,1.25 g·L^-1时, 鼻腔的吸收速率常数分别为0.0195、0.0227、0.0241 min^-1;但当药液浓度为2.5, 5.0g·L^-1时, 鼻粘膜吸收速率常数随川芎嗪浓度的增加反而减少。 结论 川芎嗪可通过鼻腔吸收, 冰片对其鼻腔吸收具有促进作用。

Nasal absorption of ligustrazine and promotion action of synthetic borneol

AIM: To investigate the nasal absorption of ligustrazine and promotion action of synthetic borneol. METHODS: In situ nasal recirculation method was used to study the dose-effect relationship of nasal absorption of ligustrazine and the effect of synthetic borneol on nasal absorption of ligustrazine in rats. RESULTS: When the concentrations of ligustrazine were 0.25, 0.75, and 1.25g·L^-1in circulation liquid, respectively, the corresponding values of the absorption rate constant k were 0.0195, 0.0227, and 0.0241 min^-1.However, when the concentrations were 2.5 and 5.0 g·L^-1 in circulation liquid, the absorption rate constant k lowered with the concentration being added. CONCLUSION: Ligustrazine can be absorbed through the nasal mucous and synthetic borneol can promote the absorption.