| 99Tcm-MIBI和99Tcm-tetrofosmin在肿瘤细胞的摄取和在荷瘤小鼠体内的分布 |
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| 引用本文： | 朱爱芝,陈丽蓉,郭秋菊,王祥云,郭振泉. 99Tcm-MIBI和99Tcm-tetrofosmin在肿瘤细胞的摄取和在荷瘤小鼠体内的分布[J]. 核化学与放射化学, 2000, 22(4) |
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| 作者姓名： | 朱爱芝 陈丽蓉 郭秋菊 王祥云 郭振泉 |
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| 作者单位： | 1. 北京大学,技术物理系,北京,100871
2. 北京大学,生命科学学院,北京,100871 |
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| 基金项目： | 国家自然科学基金资助项目! (2 97310 2 0 0 2 ) |
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| 摘 要： | 研究了小鼠黑色素瘤细胞B16、骨髓瘤细胞SP2 / 0和小鼠正常成纤维细胞ME对99Tcm MIBI和99Tcm tetrofosmin的摄取情况。结果表明 ,小鼠黑色素瘤细胞B16、骨髓瘤细胞SP2 / 0对99Tcm MIBI的摄取量高于99Tcm tetrofosmin ;小鼠正常成纤维细胞ME对99Tcm MIBI和99Tcm tetrofosmin的摄取量都很低。研究了99Tcm MIBI和99Tcm tetrofosmin在接种这两种肿瘤细胞后的小鼠体内的生物分布
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| 关 键 词： | 99TcmMIBI 99Tcmtetrofosmin 小鼠肿瘤细胞 荷瘤鼠 |
CELLULAR UPTAKE AND THE BIODISTRIBUTION IN TUMOR-BEARING MICE OF 99Tcm-MIBI AND 99Tcm-TETROFOSMIN |
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| ZHU Ai-zhi,CHEN Li-rong,GUO Qiu-ju,WANG Xiang-yun,GUO Zhen-quan. CELLULAR UPTAKE AND THE BIODISTRIBUTION IN TUMOR-BEARING MICE OF 99Tcm-MIBI AND 99Tcm-TETROFOSMIN[J]. Journal of Nuclear and Radiochemistry, 2000, 22(4) |
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| Authors: | ZHU Ai-zhi CHEN Li-rong GUO Qiu-ju WANG Xiang-yun GUO Zhen-quan |
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| Abstract: | The cellular uptake of 99 Tc m MIBI and 99 Tc m tetrofosmin in murine melanoma cell line B16,murine myeloma cell line SP2/0 and normal fibroblast line ME are studied.The results show that the uptake in tumor cells is remarkably higher than in normal cells.The biodistribution of 99 Tc m MIBI and 99 Tc m tetrofosmin in tumor bearing mice are also studied. Although the tumor to blood concentration ratios are fairly high,the overall target specificity is low. |
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| Keywords: | Tc m MIBI 99 Tc m tetrofosmin murine carcinoma cell lines tumor bearing mice |
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