A novel method for the fabrication of homogeneous hydroxyapatite/collagen nanocomposite and nanocomposite scaffold with hierarchical porosity |
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Authors: | Xinyu Shen Li Chen Xuan Cai Tong Tong Hua Tong Jiming Hu |
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Affiliation: | (1) Key Laboratory of Analytical Chemistry for Biology and Medicine, Ministry of Education, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, People’s Republic of China;(2) Chemical Engineering and Pharmacy School, Wuhan Institute of Technology, Wuhan, 430072, People’s Republic of China;(3) Center of Nano-Sciences and Nano-Technology Research, Wuhan University, Wuhan, 430072, People’s Republic of China; |
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Abstract: | Homogeneous nanocomposites composed of hydroxyapatite (HAp) and collagen were synthesized using a novel in situ precipitation
method through dual template-driven. The morphological and componential properties of nanocomposites were investigated. The
HAp particulates, in sizes of about 50–100 nm, were distributed homogeneously in the organic collagen hydrogel. Highly magnified
TEM observation showed that HAp inorganic particles were composed of fine sub-particles (2–5 nm) without regular crystallographic
orientation. Based on these homogeneous nanocomposites, a novel HAp/collagen nanocomposite scaffold with hierarchical porosity
was prepared by multilevel freeze-drying technique. Compared to other conventional scaffolds for tissue engineering, this
novel in situ method endows synthesized composite scaffolds with unique morphology—ultrafine HAp particles dispersed homogenously
in collagen at nano level and the foam scaffold with hierarchical pore structures. The mechanical performance increased obviously
compared with neat collagen. These results provided an efficient approach toward new biomimetic tissue scaffold for the biomedical
applications with enhanced intensity/bioactivity and controlled resorption rates. This novel method, we expect, will lead
to a wide application in many other hydrogel systems and may be useful for fabrication of various homogeneous inorganic/organic
nanocomposites. |
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