| 倍他米松-17-戊酸酯的合成研究 |
| |
| 引用本文： | 张宇松,金炜华,吴定伟. 倍他米松-17-戊酸酯的合成研究[J]. 浙江化工, 2011, 42(7): 8-9 |
| |
| 作者姓名： | 张宇松 金炜华 吴定伟 |
| |
| 作者单位： | 浙江仙琚制药股份有限公司,浙江仙居,317300 |
| |
| 摘 要： | 以倍他米松为原料,与原戊酸三甲酯在酸催化下发生17,21-环合,然后用稀硫酸进行21-位选择性水解得到倍他米松-17-戊酸酯,产品HPLC纯度达99.42%,反应总收率达到76.4%,经IR、1H NMR、13C NMR和MS确证结构。
|
| 关 键 词： | 倍他米松戊酸酯 糖皮质激素 合成 |
The Synthesis of Betamethasone 17-valerate |
| |
| ZHANG Yu-song,JIN Wei-hua,WU Ding-wei. The Synthesis of Betamethasone 17-valerate[J]. Zhejiang Chemical Industry, 2011, 42(7): 8-9 |
| |
| Authors: | ZHANG Yu-song JIN Wei-hua WU Ding-wei |
| |
| Affiliation: | ZHANG Yu-song,JIN Wei-hua,WU Ding-wei(Zhejiang Xianju Pharma Co.,Ltd.,Xianju,Zhejaing 317300,China) |
| |
| Abstract: | The Betamethasone 17-valerate was synthesized from betamethasone through acid catalysis 17,21-cyclization with trimethyl orthovalerate and 21-selective hydrolysis,the purity of product was 99.54% in HPLC analysis.The structure of product was identified by IR,1H NMR,13C NMR and MS.The synthetic process is simple,easy to control.The total yield was 76.4% and it is suitable for industrial production. |
| |
| Keywords: | Betamethasone 17-valerate Glucocorticoid synthesis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
