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Composite core-double sheath fibers based on some biodegradable polyesters obtained by self-organization during electrospinning |
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| Authors: | Selin Kyuchyuk Dilyana Paneva Nevena Manolova Iliya Rashkov Daniela Karashanova Nadya Markova |
| Affiliation: | 1. Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, Sofia, Bulgaria Contribution: Data curation (equal), Formal analysis (equal), Investigation (equal), Methodology (equal), Validation (equal), Visualization (equal), Writing - original draft (equal);2. Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, Sofia, Bulgaria;3. Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, Sofia, Bulgaria Contribution: Conceptualization (equal), Data curation (equal), Methodology (equal), Supervision (equal), Writing - original draft (equal), Writing - review & editing (lead);4. Laboratory “Electron Microscopy”, Institute of Optical Materials and Technologies, Bulgarian Academy of Sciences, Sofia, Bulgaria Contribution: Data curation (equal), Investigation (equal), Validation (equal);5. Department of Infectious Microbiology, Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria Contribution: Data curation (equal), Investigation (equal), Validation (equal) |
| Abstract: | Obtaining core-sheath fibers by single-spinneret electrospinning is a recent and straightforward approach to prepare composite fibers. Fibers of more complex architecture consisting of poly(ethylene oxide) (PEO) core, inner poly(l -lactide) sheath sd and outer beeswax (BW) sheath may also be obtained using this method. In the present study we report its applicability for a large series of (bio)degradable polyesters such as poly(ε-caprolactone), poly(d ,l -lactide-co-glycolide), poly(butylene succinate), poly(3-hydroxybutyrate), and poly(l -lactide-co-d ,l -lactide). The fibers have a well-differentiated PEO core, polyester inner sheath and BW outer sheath. The possibility for targeted location of hydrophilic or hydrophobic substances in the core or in the sheaths of the PEO/polyester/BW fibers has been demonstrated using nanosized zinc oxide with unmodified (hydrophilic) or silanized (hydrophobic) surface. PEO/polyester/BW fibrous materials loaded with a model drug (5-nitro-8-hydroxyquinoline) exhibit antimicrobial activity. The obtained results show that single-spinneret electrospinning is a novel and versatile method to prepare core-double sheath composite fibers prospective for various applications such as biomedicine, cosmetics, and food packaging. |
| Keywords: | antimicrobial beeswax biodegradable polyester core-sheath fibers electrospinning poly(ethylene oxide) self-organization |