Randomized controlled study of the urinary excretion of biophenols following acute and chronic intake of olive leaf supplements |
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| Authors: | Megan Kendall Marijka Batterham Damien L. Callahan Daniel Jardine Paul D. Prenzler Kevin Robards Danielle Ryan |
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| Affiliation: | 1. Charles Sturt University, EH Graham Centre for Agricultural Innovation, School of Agricultural and Wine Sciences, Wagga Wagga 2678, Australia;2. Centre for Statistical and Survey Methodology, University of Wollongong, Northfields Ave., Wollongong 2522, Australia;3. Metabolomics Australia, School of Botany, The University of Melbourne, Victoria 3010, Australia;4. Flinders Analytical, Faculty of Science & Engineering, Flinders University, Adelaide, SA 5001, Australia |
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| Abstract: | Olive leaf supplement was characterised by HPLC and administered to healthy young adults over 28 d (three tablets or equivalent liquid dose per day), or in a single bolus dose of three tablets (or liquid equivalent). Oleuropein was the major biophenol in the extracts. There are no data on the excretion of urinary end-products of the metabolism of the olive leaf biophenols. Following both chronic and acute ingestion neither oleuropein, nor its hydrolysis product, hydroxytyrosol, were detected in urine samples. However, glucuronic acid conjugates, derived from oleuropein aglycone were detected in all urine samples up to 6 h following acute ingestion. The data suggest that oleuropein is bioavailable, which is a necessary pre-condition for bioactivity. |
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