Borrelidin is an angiogenesis inhibitor; disruption of angiogenic capillary vessels in a rat aorta matrix culture model |
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Authors: | T Wakabayashi R Kageyama N Naruse N Tsukahara Y Funahashi K Kitoh Y Watanabe |
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Affiliation: | Tsukuba Research Laboratories, Eisai, Co., Ltd., Ibaraki, Japan. |
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Abstract: | Borrelidin, an antibiotic from Streptomyces rochei, was found to be an angiogenesis inhibitor in a rat aorta matrix culture model which forms capillary vessels in vitro. Borrelidin strongly inhibited capillary tube formation with a 50%-inhibitory concentration value of 0.8 nM, and decreased the number of capillary tubes within 24 hours when added after maturation of tube formation. Borrelidin remarkably disrupted capillary tubes in a dose-dependent manner, by inducing apoptosis of the tube-forming cells. |
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