| 单端马来酰亚胺基功能化聚乙二醇的制备 |
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| 引用本文： | 王婷,孟庆斌,王晨宏,倪才华.单端马来酰亚胺基功能化聚乙二醇的制备[J].应用化工,2012(3):438-441,444. |
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| 作者姓名： | 王婷 孟庆斌 王晨宏 倪才华 |
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| 作者单位： | 江南大学化学与材料工程学院;军事医学科学院毒物药物研究所 |
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| 摘 要： | 以PEG2000为初始原料,通过与小分子的反应,将其一端羟基保留,得到NH2-PEG2000-OH,然后将NH2-PEG2000-OH与6-(马来酰亚胺基)己酸琥珀酰亚胺酯反应,得到单端马来酰亚胺基修饰的聚乙二醇(Mal-(CH2)5-CONH-PEG2000-OH)。经过1H NMR验证,结果表明,通过这条合成路线能够成功得到单端马来酰亚胺基功能化的聚乙二醇。
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| 关 键 词： | 聚乙二醇(PEG) 单端功能化 马来酰亚胺 |
Preparation of monofunctional maleimido-poly(ethylene glycol) |
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| WANG Ting,MENG Qing-bin,WANG Chen-hong,NI Cai-hua.Preparation of monofunctional maleimido-poly(ethylene glycol)[J].Applied chemical industry,2012(3):438-441,444. |
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| Authors: | WANG Ting MENG Qing-bin WANG Chen-hong NI Cai-hua |
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| Affiliation: | 1 (1.School of Chemical and Material Engineering,Jiangnan University,Wuxi 214122,China; 2.Institute of Pharmacology and Toxicology,Academy of Military Medical Sciences,Beijing 100850,China) |
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| Abstract: | With PEG2000 as initial material,NH2-PEG2000-OH was first synthesized from OH-PEG2000-OH,and then Mal-(CH2)5-CONH-PEG2000-OH was made from NH2-PEG2000-OH and 6-maleimidohexanoic acid N-hydroxysuccinimide ester.The structure of the final product and intermediates were characterized and confirmed by 1H NMR.The results revealed that the heterobifunctional PEG with a maleimide group on one end and a hydroxyl group at the other can be obtained by this method. |
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| Keywords: | poly(ethylene glycol)(PEG) heterobifunctional maleimide |
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