Design and in Vitro Evaluation of a Controlled Release Drug Delivery System of Sulfasomidine

A controlled release oral drug delivery system of Sulfasomidine was developed by spray congealing micropelleting technique using gelatin as the embedding matrix. The pellets were hardened by treating with Formalin-Isopropanol mixture. The in vitro release rate studies of Sulfasomidine from the micropelleted dosage form, revealed that the drug release can be prolonged upto eight hours and not more than 39% of the embedded drug released in the first hour of the in vitro dissolution study. The in vitro release patterns correlated with the reported in vivo studies. The method of formulation was optimized.