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Synthesis,Characterization and Immunological Evaluation of Self‐Adjuvanting Group A Streptococcal Vaccine Candidates Bearing Various Lipidic Adjuvanting Moieties |
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| Authors: | Dr. Vincent Fagan Dr. Waleed M. Hussein Mei Su Ashwini K. Giddam Dr. Michael R. Batzloff Prof. Michael F. Good Prof. Istvan Toth Dr. Pavla Simerska |
| Affiliation: | 1. School of Chemistry and Molecular Biosciences, The University of Queensland, St.?Lucia, QLD, Australia;2. Institute for Glycomics, Griffith University, Gold Coast, Australia;3. School of Pharmacy, Pharmacy Australia Centre of Excellence, The University of Queensland, Woolloongabba, QLD, Australia;4. Institute for Molecular Bioscience, The University of Queensland, St.?Lucia, QLD, Australia |
| Abstract: | Four group A streptococcal glycolipopeptide vaccine candidates with different lipidic adjuvanting moieties were prepared and characterized. The immunogenicity of the compounds was evaluated by macrophage and dendritic cell uptake studies and by in vivo quantification of systemic IgG antibody by ELISA. Three of the candidates showed significant induction of the IgG response. |
| Keywords: | adjuvant antigens immunology lipopeptide vaccine toll-like receptor 2 |