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Suzuki Coupling of Amides via Palladium‐Catalyzed C–N Cleavage of N‐Acylsaccharins |
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| Authors: | Hongxiang Wu Yue Li Ming Cui Junsheng Jian Zhuo Zeng |
| Abstract: | A palladium‐catalyzed cross‐coupling of activated amides with arylboronic acids has been developed via C–N bond cleavage. This approach demonstrated high tolerance to a variety of alkyl, aryl, heterocyclic and vinyl substituents. Unsymmetrical ketones could be achieved in excellent yield under mild conditions with 1% catalyst loadings.  |
| Keywords: | N-acylsaccharins C– N bond cleavage ketones Suzuki coupling twisted amides |