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The Reactivity of Difluorocarbene with Hydroxylamines: Synthesis of Carbamoyl Fluorides |
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| Authors: | Hannah Baars Julien Engel Lucas Mertens Daniela Meister Carsten Bolm |
| Abstract: | Carbamoyl fluorides are formed in reactions of hydroxylamines with difluorocarbene generated from sodium bromodifluoroacetate as readily available and non‐toxic carbene precursor. The process shows a high functional group tolerance, and the reaction path has been rationalized by computational calculations.  |
| Keywords: | carbenes fluorine reaction mechanism synthetic methods |