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Four‐Electron Electrocyclic Ring‐Opening/Intermolecular [4+2] Cycloadditions of α‐Hydroxycyclobutenones: Stereoselective Synthesis of Multiple Substituted δ‐Lactams |
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| Authors: | Peidong Song Qing Li Congcong Wang Wenfa Wu Xu Mao Jiajia Wang Xiangdong Hu |
| Abstract: | A four‐electron electrocyclic ring‐opening/intermolecular 4+2] cycloaddition of α‐hydroxycyclobutenones is reported. The reaction represents the first example for the intermolecular cycloaddition of the extensively studied enol‐ketene intermediate, and provides a new synthetic route to multiply substituted δ‐lactams in high stereoselectivity.  |
| Keywords: | enol‐ketene intermediates α ‐hydroxycyclobutenones intermolecular [4+2] cycloaddition δ ‐lactams stereoselectivity |