| 聚乳酸-氨基酸共聚物的合成及表征 |
| |
| 引用本文： | 董锐,郑雪琴,唐兰勤. 聚乳酸-氨基酸共聚物的合成及表征[J]. 当代化工, 2009, 38(6): 559-562 |
| |
| 作者姓名： | 董锐 郑雪琴 唐兰勤 |
| |
| 作者单位： | 1. 盐城工学院材料科学与工程学院,江苏,盐城,224051
2. 盐城工学院化学与生物工程学院,江苏,盐城,224051 |
| |
| 摘 要： | 以乳酸（LA）、氨基酸（赖氨酸,L-L）、聚乙二醇（PEG）为单体,氯化亚锡（SnCl2）为催化剂,采用直接熔融缩聚法合成了医用生物可降解材料。通过四因素三水平的正交实验得出聚乳酸-氨基酸共聚的最佳反应条件为：LA、氨基酸（赖氨酸）、PEG的摩尔比为85∶10∶5,催化剂m（SnCl2）∶m（LA）=0.007,聚合时间为10h,聚合温度为110℃。产物的最大室温特性黏度为0.2197dL/g。
|
| 关 键 词： | 熔融聚合 聚乳酸 氨基酸 生物降解材料 |
Synthesis and Characterization of Poly (lactic acid-co-amino acid) Copolymers |
| |
| DONG Rui,ZHENG Xue-qin,TANG Lan-qin. Synthesis and Characterization of Poly (lactic acid-co-amino acid) Copolymers[J]. Contemporary Chemical Industry, 2009, 38(6): 559-562 |
| |
| Authors: | DONG Rui ZHENG Xue-qin TANG Lan-qin |
| |
| Affiliation: | DONG Rui,ZHENG Xue-qin, TANG Lan-qin ( 1.College of Materials Science and Engineering, Yancheng Institute of Technology, Jiangsu Yancheng 224051, China; 2.College of Chemical and Biological Engineering, Yancheng Institute of Technology, Jiangsu Yancheng 224051, China) |
| |
| Abstract: | A kind of biodegradable medical material was synthesized via direct melt polymerization of lactic acid（LA）,lysine（L-L）and polyethylene glycol（PEG） with SnCl2 as catalyst. The best reaction conditions of Poly（lactic acid-co-amino acid）copolymerization were gained by the orthogonal design of four factors and three levels. The results indicate that the optimum conditions are as follows：molar ratio of LA/L-L/PEG is 85∶10∶5,weight ratio of SnCl2 to LA is 0.007,reaction time is 12 h and reaction temperature is 110 ℃. The maximum viscosity of obtained copolymers is 0.219 7 dL/g. |
| |
| Keywords: | Melt Polymerization Polylactic Acid Amino Acid Biodegradable Material |
| 本文献已被 维普 万方数据 等数据库收录！ |
|
