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研究了在溴化十六烷基三甲胺(CTMAB)存在下,2-羟基-3-甲氧基苯基荧光酮与钨(Ⅵ)显色反应的条件。结果表明,在0.32 mol/L硫酸介质中,2-羟基-3-甲氧基苯基荧光酮与钨(Ⅵ)形成一种桔红色的络合物,其最大吸收峰位于516 nm,表观摩尔吸光系数为1.3×105L.mol-1.cm-1,在25 mL溶液中,钨量在0~12μg范围内符合比尔定律。分析方法可用于合金钢中微量钨的测定,相对标准偏差为1.6%~5.3%,结果与认定值相符合。 相似文献
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合成了新显色剂9-(2-羟基-5-偶氮对甲苯)苯基荧光酮(HMAPPF),并采用红外、核磁和质谱分析确定其分子结构。在研究新试剂与钼Ⅵ显色反应基础上,建立了测定合金钢中微量钼的光度分析方法。在盐酸、磷酸及CTMAB存在下,钼Ⅵ与HMAPPF室温立即反应,生成红色络合物,体系至少可以稳定12h以上。钼络合物的最大吸收峰位于522nm,表观摩尔吸光系数达1.54×105L.mol-1.cm-1,在25mL溶液中,钼Ⅵ量在0~12μg范围内符合比尔定律。此外,该显色反应体系具有良好的选择性,绝大多数金属离子有较 相似文献
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报道了新试剂5-安替比林偶氮水杨基荧光酮(APASF)的合成方法,研究了在表面活性剂十六烷基三甲基溴化铵(CTMAB)存在下试剂与钨的显色反应。将4-氨基安替比林重氮化制得重氮盐溶液,然后水杨醛与重氮盐反应合成安替比林偶氮水杨醛,将事先合成的偏三酚三乙酸酯与安替比林偶氮水杨醛反应合成APASF,并用红外光谱分析法对其进行表征。产率为40%。在酸性介质中,表面活性剂十六烷基三甲基溴化铵(CTMAB)存在下,试剂与钨生成络合物的最大吸收波长为520 nm,表观摩尔吸光系数为7.4×104L.mol-1.cm-1,钨的质量浓度在0.1~1.0μg/mL范围内符合比尔定律。方法用于标准钢样中钨的测定,测得值与认定值相符。 相似文献
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研究了在阳离子表面活性剂溴化十六烷基三甲铵(CTMAB)存在下,9-(3,5-二溴)水杨基荧光酮(DBSAF)与镧(的显色反应及光度性能,建立了测定镧(的新方法。在pH 10.5NH3.H2O-NH4Cl缓冲溶液中,La(与DBSAF及CTMAB形成摩尔比为1∶2∶4的紫红色三元络合物,其最大吸收峰位于566.0 nm波长处,表观摩尔吸光系数为1.03×105L.mol-1.cm-1,在25 mL溶液中镧(量在0~24μg范围内符合比尔定律。该法已用于电子工业钛酸镧烧结中游离氧化镧的测定。 相似文献
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E Falch L Brehm I Mikkelsen TN Johansen N Skjaerbaek B Nielsen TB Stensb?l B Ebert P Krogsgaard-Larsen 《Canadian Metallurgical Quarterly》1998,41(14):2513-2523
We have previously shown that (S)-2-amino-3-(3-hydroxy-5-phenyl-4-isoxazolyl)propionic acid [(S)-APPA, 2] is a weak agonist at (RS)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA) receptors, specifically activated by (S)-AMPA (1), whereas (S)-2-amino-3-[3-hydroxy-5-(2-pyridyl)-4-isoxazolyl]propionic acid [(S)-2-Py-AMPA, 5] and (RS)-2-amino-3-[3-hydroxy-5-(2-thiazolyl)-4-isoxazolyl]propionic acid (4) are potent AMPA agonists. On the other hand, (R)-APPA (3) and (R)-2-Py-AMPA (6) have been shown to be weak AMPA antagonists. We now report the synthesis of 2-Py-AMPA (7a) and the isomeric compounds 3-Py-AMPA (7b) and 4-Py-AMPA (7c) as well as the 7a analogues, (RS)-2-amino-3-[3-hydroxy-5-(6-methyl-2-pyridyl)-4-isoxazolyl]p ropion ic acid (7d) and (RS)-2-amino-3-[3-hydroxy-5-(2-quinolinyl)-4-isoxazolyl]propionic acid (7e). Furthermore, (RS)-2-amino-3-[3-hydroxy-5-(2-furyl)-4-isoxazolyl]propionic acid (2-Fu-AMPA, 7f) and its 5-bromo-2-furyl derivative (7g) were synthesized, and (S)-2-Fu-AMPA (8) and (R)-2-Fu-AMPA (9) were prepared by semipreparative chiral HPLC resolution of 7f. HPLC analyses and circular dichroism spectroscopy indicated the absolute stereochemistry of 8 and 9 to be S and R, respectively. This was confirmed by an X-ray crystallographic analysis of 9.HCl. In receptor binding (IC50 values) and rat cortical wedge electrophysiological (EC50 values) studies, 7c (IC50 = 5.5 +/- 0.6 microM; EC50 = 96 +/- 5 microM) was shown to be markedly weaker than 7a (IC50 = 0.57 +/- 0.16 microM; EC50 = 7.4 +/- 0.2 microM) as an AMPA agonist, whereas 7b,d,e were inactive. The very potent AMPA agonist effect of 7f (IC50 = 0.15 +/- 0.03 microM; EC50 = 1.7 +/- 0. 2 microM) was shown to reside exclusively in 8 (IC50 = 0.11 +/- 0.01 microM; EC50 = 0.71 +/- 0.11 microM), whereas 9 did not interact significantly with AMPA receptors, either as an agonist or as an antagonist. 8 was shown to be photochemically active and is a potential photoaffinity label for the recognition site of the AMPA receptors. Compound 7g turned out to be a very weak AMPA receptor agonist (IC50 = 12 +/- 0.7 microM; EC50 = 160 +/- 15 microM). None of these new compounds showed detectable effects at N-methyl-d-aspartic acid (NMDA) or kainic acid receptors in vitro. The present studies have emphasized that the presence of a heteroatom in the 2-position of the heteroaryl 5-substituent greatly facilitates AMPA receptor agonist activity. 相似文献
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合成了新显色剂2-[(对-苯偶氮苯)-三氮烯]苯甲酸(PABTB),并研究了该试剂在阳离子表面活性剂CTMAB存在下与锑离子的显色反应。将邻氨基苯甲酸重氮化得到重氮盐溶液,然后重氮盐与对氨基苯偶氮苯发生偶联反应,产物经提纯和重结晶后得到PABTB。通过元素分析和红外光谱检验确认其为目标产物。在pH 10.18的硼砂和氢氧化钠缓冲溶液介质中,锑与该试剂形成摩尔比为1∶2的红色络合物,其表观摩尔吸光系数为1.686×105L.mol-1.cm-1,锑离子的浓度在0~0.7 mg/L范围内符合比尔定律。用该试剂成功地测定了矿样中微量锑。 相似文献
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M Scalzo M Artico R Giuliano F Chimenti S Vomero V Nacci 《Canadian Metallurgical Quarterly》1977,32(8):579-592
The synthesis of some pyrrolobenzodiazepine derivatives related to oxotomaymycin, an antibiotic recovered together with tomaymycin from fermentation broths of Streptomyces achromogenes var. tomaymycetics, is described. Reaction between 2-nitro-4-benzyloxy-5-methoxybenzylbromide and pyrrole-2-carboxyaldehyde afforded 1-(2-nitro-4-benzyloxy-5-methoxybenzyl)pyrrole-2-carboxyaldehyde. Catalytic reduction of this compound with hydrogen in the presence of Pd/C gave 10,11-dihydro-8-hydroxy-7-methoxy-5H-pyrrolo[2.1-c] [1,4]benzodiazepine. Amides obtained from condensation between 2-nitro-4-benzyloxy-5-methoxybenzoic acid chloride and proline or hydroxyproline were reduced catalytically to 2,3-dihydro-8-hydroxy-7-methoxy-1H-pyrrolo [2,1-c] [1,4]benzodiazepine-5,11 (10H, 11aH)-dione and its 2-hydroxyderivative respectively. The synthesis of 10,11-dihydro-8-hydroxy-9-methoxy-5-pyrrolo [2,1-c] [1,4]benzodiazepine is also reported. 相似文献
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MT Garcia-Conesa GW Plumb KW Waldron J Ralph G Williamson 《Canadian Metallurgical Quarterly》1997,3(5-6):319-323
Wheat bran contains several ester-linked dehydrodimers of ferulic acid, which were detected and quantified after sequential alkaline hydrolysis. The major dimers released were: trans-5-[(E)-2-carboxyvinyl]-2-(4-hydroxy-3-methoxy-phenyl)-7-methoxy-2, 3- dihydrobenzofuran-3-carboxylic acid (5-8-BendiFA), (Z)-beta-[4-[(E)-2-carboxyvinyl]-2-methoxyphenoxy]-4-hydroxy-3-methox ycinnamic acid (8-O-4-diFA) and (E,E)-4,4'-dihydroxy-5,5'-dimethoxy-3,3'-bicinnamic acid (5-5-diFA). trans-7-hydroxy-1-(4-hydroxy-3methoxyphenyl)-6-methoxy-1,2-dihydro - naphthalene-2,3-dicarboxylic acid (8-8-diFA cyclic form) and 4,4'-dihydroxy-3,3'-dimethoxy-beta,beta'-bicinnamic acid (8-8-diFA non cyclic form) were not detected. One of the most abundant dimers, 8-O-4-diFA, was purified from de-starched wheat bran after alkaline hydrolysis and preparative HPLC. The resultant product was identical to the chemically synthesised 8-O-4-dimer by TLC and HPLC as confirmed by 1H-NMR and mass spectrometry. The absorption maxima and absorption coefficients for the synthetic compound in ethanol were: lambda max: 323 nm, lambda min: 258 nm, epsilon lambda max (M-1 cm-1): 24,800 +/- 2100 and epsilon 280 (M-1 cm-1): 19,700 +/- 1100. The antioxidant properties of 8-O-4-diFA were assessed using: (a) inhibition of ascorbate/iron-induced peroxidation of phosphatidylcholine liposomes and; (b) scavenging of the radical cation of 2,2'-azinobis (3-ethyl-benzothiazoline-6-sulphonate) (ABTS) relative to the water-soluble vitamin E analogue, Trolox C. The 8-O-4-diFA was a better antioxidant than ferulic acid in both lipid and aqueous phases. This is the first report of the antioxidant activity of a natural diferulate obtained from a plant. 相似文献
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用铝酸钡和氢氧化钡对种分母液进行脱硫试验,对脱硫渣进行XRD分析,并比较脱硫过程。结果表明,氢氧化钡的脱硫效果更好,脱硫完成时间更短,速率更快;铝酸钡先与碱液反应生成2BaO.Al2O3.5H2O,再与硫碱和碳碱反应,而氢氧化钡直接与硫碱和碳碱反应,脱硫过程均可用未反应核模型描述。 相似文献
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利用斐了子型表面活性剂OP存在下,5-Br-DMPAP与铋的反应来测钢铁及合金中铋。干扰元素用DDTC-DDl4萃取法分离,HCl(1+1)反萃取后随铋主的微量铁以抗坏血酸掩蔽,反应适宜酸度为pH3左右。采用0.1M-氯醋酸和M醋酸钠(1+1)混合液为缓冲液,络合物Bi-5-Br-DMPAP最大吸收峰在575nm处。 相似文献
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在含有十六烷基三甲基溴化胺(CTMAB)的磷酸盐(PBS)缓冲溶液中,Zn2+对高碘酸钠氧化荧光桃红的反应具有显著的催化效应,催化的结果是导致其荧光强度显著减弱。据此建立了基于Zn2+和银纳米粒子协同双催化效应动力学荧光法测定痕量Zn2+的新方法。实验结果表明pH 7.8的磷酸盐缓冲溶液中,当荧光桃红、NaIO4、银纳米粒子、CTMAB溶液浓度分别为2.0×10-6 mol/L,5.0×10-3 g/L,5.0×10-6 mol/L ,1.5×10-3 g/L时,Zn2+的浓度在5×10-8 ~ 100×10-8 g/L范围内与体系的荧光强度改变值呈良好的线性关系,检出限为1.88×10-8 g/L。应用于电镀工业废水中Zn2+的检测,测定值与双硫腙光度法基本一致,相对标准偏差(RSD,n=6)≤2.5%。 相似文献