共查询到18条相似文献,搜索用时 156 毫秒
1.
综述了近几年来环糊精与药物分子形成包合物在医药应用上的新进展,即①超声波法合成药用环糊精包合物;②新型药用环糊精包合物的制备;③环糊精及其衍生物对药物的增溶作用。 相似文献
2.
制备出苏云金芽孢杆菌(B.t.)β-环糊精包合物,并对包合物进行了差热分析,证明B.t.原粉被β-环糊精包合。室内生物活性测定结果表明,当B.t.原粉与β-环糊精质量比为0.5:2时,包合物对棉铃虫2龄幼虫的杀虫活性最高,确定包合物中B.t.原粉与肛环糊精的最佳质量比为0.5:2。盆栽药效试验结果表明,当B.t.原粉制成环糊精包合物后,与B.t.原粉和B.t.制剂相比,对小菜蛾的防效明显提高。药剂处理后1、3、7d,B.t.环糊精包合物对小菜蛾的防效分别为41.67%、61.54%和60.00%,而B.t.原粉和制剂的防效分别为23.61%、38.46%、32.00%和31.94%、52.31%、46.00%。 相似文献
3.
4.
本文介绍了环糊精,环糊精的包合作用,环糊精包合物的特征、意义以及其应用前景。同时,着重对环糊精包合物在医药研究方面的具体实例进行了介绍,如:阿莫西林、丁吡吗啉、利福平、阿魏酸等药物制备的环糊精包合物。 相似文献
5.
6.
环糊精包合物的研究进展 总被引:1,自引:0,他引:1
《广东化工》2015,(19)
20世纪70年代初到现在,环糊精化学的研究进入了鼎盛时期,随着经济的不断发展,环糊精包合物的研究越来越广泛,在许多方面都表明出其具有独特的作用。环糊精包合物的制备、表征和应用研究一直是环糊精化学的重要内容。文章主要介绍了环糊精包合物在制备时常采用的三种方法,以及对其表征时常采用的方法进行一定的阐述,详细概括了环糊精包合物的形成因素,并对于环糊精的包合物在今后的应用以及展望进行了讨论。 相似文献
7.
8.
环糊精包合客体分子机理的研究 总被引:12,自引:0,他引:12
环糊精具有独特的疏水空腔结构,与一些物质包合后.能显著改变这些物质的理化性能。本文在环糊精包合染料的基础上,探讨了环糊精包合客体分子的机理。认为包合物形成主要取决于环糊精和客体分子结构及两者作用力的大小。客体分子或其中某些基团的大小与环糊精空腔大小相近的易于包合,两者之间的作用力大小影响包合物的稳定性,疏水力是包合过程主要推动力。 相似文献
9.
10.
11.
Cyclodextrins (CD) are produced from starch by the action of cyclodextrin glycosyltransferase (CGTase) enzyme. Structurally, cyclodextrins consist of 6, 7, or 8 (α, β, and γ cyclodextrins, respectively) D‐glucopyranosyl units connected by α‐(1,4) glycosidic linkages. Having polar and hydrophilic outer sides and hydrophobic cavitation gives cyclodextrins a chance to form inclusion complexes with dyes in hydrophilic mediums. In this research, the equalizing effect of β‐cyclodextrins in dyeing of polyamide 6,6 woven fabrics with 6 different acid dyes were investigated. From the experimental results, it was determined that the β‐cyclodextrin shows a retarding and equalizing effect in dyeings carried out with the dyes that show interaction with β‐CD. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 103: 2660–2668, 2007 相似文献
12.
13.
14.
Poly(vinyl alcohol) (PVA) hydrogels containing drug–β‐cyclodextrin inclusion complexes (ICs) were synthesized with glutaraldehyde (GA) as a crosslinker. The role of cyclodextrin (CD), the effect of the nature of drug, and the degree of crosslinking on the drug‐release process were investigated. The probable mechanism of drug release was also explored. Controlled release of the drug was achieved from the hydrogels containing the ICs. The nature of the drug, in terms of its binding efficacy with CD, played an important role. The effect of the degree of crosslinking on the release pattern was strikingly different from that in the hydrogels containing free drug and those with ICs. The role of CD in the drug‐release process was not only due to its inclusion ability but also its effect on the polymer relaxation. GA, apart from crosslinking PVA, probably interacted with the cyclodextrins and, thereby, influenced the matrix structure and the drug‐release kinetics. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014 , 131, 40318. 相似文献
15.
《Chemical Engineering and Processing: Process Intensification》2006,45(3):175-183
The separation of aromatic compounds (toluene and o-xylene) from heptane and of benzyl alcohol from toluene with aqueous solutions of cyclodextrins has been experimentally investigated, because cyclodextrins and its derivatives can selectively incorporate several organic compounds, whereas the separation of the aqueous solution of complexed cyclodextrins from the organic feed is simple. Cyclodextrins are not soluble in organic liquids, but cyclodextrin derivatives are highly soluble in water. Hydroxypropyl-β-cyclodextrins with different degrees of substitution and methylated β-cyclodextrin were selected for the extraction of toluene and o-xylene from heptane. Hydroxypropyl-β-cyclodextrin (two different substitution degrees) and hydroxypropyl-α-cyclodextrin were selected for the extraction of benzyl alcohol from toluene. The liquid–liquid distribution experiments were carried out at room temperature. Toluene and o-xylene form 1:1 complexes with different cyclodextrins and heptane can form 1:1 to 1:3 complexes. Benzyl alcohol forms 1:3 complexes with hydroxypropylated cyclodextrins. The models developed describe the experimental data reasonably well, considering the large deviations in the analyses.Aqueous cyclodextrin solutions are not feasible for the separation of aromatic components from aliphatic hydrocarbons, due to low distribution ratios of toluene (0.05) and o-xylene (0.023) between the aqueous and organic phase. With high distribution ratios of benzyl alcohol, between 0.3 and 2.2 depending on the CD concentration (at a solvent-to-feed ratio of 1) and a benzyl alcohol/toluene selectivity of at least 100, aqueous hydroxypropylated cyclodextrin solutions have sufficient potential for extracting benzyl alcohol from toluene. 相似文献
16.
表面张力法是研究环精精与表面活性剂相互作用的有力工具,用表面张力--表面活性剂浓度(γ-C)曲线来计算包结化合物的形成常数是可行的。本介绍了六种用表面张力法计算环糊精-表面活性剂包结化合和形成常数的数值处理方法。 相似文献
17.
环糊精超分子包结物的制备与应用前景 总被引:4,自引:0,他引:4
环糊精具有“内疏水,外亲水”的空腔,可与多种客体形成包结构,并改善客体的特性,因而被广泛应用。综述了环糊精包结物的制备及其衍生物超分子包结构的应用领域。 相似文献
18.
Cyclodextrins can form inclusion complexes with different molecules with the aid of their special chemical (molecular) structures. Physical and chemical properties of molecules can change after the formation of complex. This special feature enables the usage of dextrins in different industry areas. In this study, applicability of cylcodextrins in textile dyeing and washing processes was investigated. With this aim, β‐cyclodextrin was used in direct dyeing of cellulosic fabrics and in rinsing processes of direct dyed fabrics. Retarder/leveling effect of β‐cyclodextrin in dyeing process has been studied and the results were compared with that of a commercial product. In general, cyclodextrins were used in washing processes to remove the absorbed surfactants. It has been investigated whether this effect was the same for washing of dyed fabrics. Eight different direct dyes, for which the chemical structures are known, were used in dyeing and washing processes, and effect of β‐cyclodextrin on different chemical structures was investigated. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 100: 208–218, 2006 相似文献