环烷烃及其衍生物的开环催化剂研究进展

综述了国内外在单环及多环化合物选择性开环催化剂的研究进展情况,重点介绍了甲基环戊烷,四氢萘,八氢菲等环烷烃或芳烃化合物的选择性开环反应,总结了不同化合物的选择性开环所需的催化剂,并对选择性开环催化剂的发展前景进行了展望。     

环烷烃及其衍生物的开环催化剂研究进展

综述了国内外在单环及多环化合物选择性开环催化剂的研究进展情况,重点介绍了甲基环戊烷,四氢萘,八氢菲等环烷烃或芳烃化合物的选择性开环反应,总结了不同化合物的选择性开环所需的催化剂,并对选择性开环催化剂的发展前景进行了展望。     

大环多胺与其它大环化学研究的新进展

介绍了新型大环多胺及其衍生物的结构特点、应用、络合物性能及对分子离子识别作用的新进展。重点综述了近年来各类新型大环多胺及其衍生物的合成、配合物的形成、对分子离子的识别、催化、选择性络合及新应用,展望了其广阔的应用前景。期望能在医药学、生命科学、材料科学、环境科学及能源科学的应用上更有意义。     

杯芳烃及其衍生物在色谱分离中的应用

杯芳烃是由多个苯酚在 2 ,6位通过亚甲基相连形成的大环化合物。它是继环糊精和冠醚之后的第三代超分子物质 ,兼有环糊精、冠醚之所长 ,具备更高的选择性。其分子识别功能在现代分离科学中有着广泛的应用。本文对其在色谱分离中的应用进行了综述和展望     

3-环丙基-1-甲基-1H-吡唑-4-甲醛的合成研究

以环丙基甲基酮和二甲氧基-N,N-二甲基甲胺为起始原料,依次通过羟醛缩合、与肼缩合成环、选择性甲基化反应和Vilsmeier-Hack反应得到目标产物3-环丙基-1-甲基-1H-吡唑-4-甲醛(化合物1),总收率高达48.0%。     

核苷及核苷酸类化合物的化学结构研究进展

核苷及核苷酸类化合物是生命体中一类重要的小分子化合物,具有广泛的生物活性。但是目前对核苷及核苷酸类化合物主要集中于化学合成和检测,对其化学结构的概括和分析研究较少。本文通过国内外文献调研,整理了核苷及核苷酸类化合物的化学结构,为核苷类化合物的进一步应用和开发提供参考。     

大环三胺类化合物合成方法的研究进展

大环三胺类化合物是一类非常重要的化合物,但其合成比较困难,存在合成步骤多、产率低等问题。对大环三胺单体及其衍生物的合成方法进行了探讨,为大环三胺类化合物的相关研究提供了参考。     

杯芳烃衍生物对Ca2+识别研究进展

杯芳烃是由多个苯酚在2,6位与亚甲基相连形成的大环化合物,具有分子识别功能,是继环糊精和冠醚之后第三代主体分子.本文综述了近年来杯芳烃衍生物对钙离子高度识别性的研究进展.     

2，4，6-三氯-3-甲基苯胺和2，6-二氯-3-甲基苯胺的合成

芳胺类化合物的二氯代物是重要的合成农药的中间体,如2,6-二氯间甲基苯胺可用于除草剂磺草唑胺（metosulam）的合成,但芳胺类化合物2、4、6位氢都有较强的反应活性,所以需要2、6位氢被取代,4位氢不被取代,这就要求对4位氢进行占位。磺酸基和磺酰胺基是常用的芳环占位基团,以3-甲基苯胺的氯化为例,讨论磺酸基和磺酰胺基占位对芳胺2、6位选择性的影响。以3-甲基苯胺为原料,经烘培磺化、氯化、脱磺酸基来制备2,6-二氯间甲基苯胺。     

大环多胺Fe(Ⅲ)配合物催化环己烯环氧化反应

利用2,2-二乙基丙二酰氯、2,2-二甲基丙二酰氯或2,2-二氟丙二酰氯与α-氨基异丁酸、双(三氯甲基)碳酸酯、4,5-二氯邻苯二胺以及铁离子制得大环多胺Fe(Ⅲ)配合物,考察了反应温度、H2O2用量、大环多胺配体的结构和大环多胺Fe(Ⅲ)配合物的用量对环已烯环氧化反应的影响.结果表明,该催化剂在CH2Cl2中,以H2...     

The use of macrocyclic compounds as electrocatalysts in fuel cells

Macrocyclic compounds such as metallophthalocyanines demonstrated good catalytic activities toward electrochemical reactions. The characteristics of the central cations in metallophthalocyanines significantly influenced their electrocatalytic activities. Addition of conjugated polymers in electrodes improved the electrocatalytic activity by enhancing the electric conductivity. The electrocatalytic activities of macrocyclic compounds could be further improved by heat treatment. The formation of metallic clusters or metal containing organic fragments after pyrolyzing played an important role in improving electrocatalytic activities of macrocyclic compounds. It was considered that macrocyclic compounds might be functioned as a precursor to obtain well-distributed metallic clusters or metal containing organic fragments.     

苯硼酸及其衍生物在医药与化工领域的应用研究进展

苯硼酸及其衍生物可以与多羟基化合物（多糖、糖脂、糖蛋白及核苷酸等物质）形成可逆络合物,因此可用于这些物质的识别、分离与检测。综述了苯硼酸及其衍生物在自律式胰岛素给药系统、组织工程、生物物质分离系统以及传感器方面的应用研究进展,展望了苯硼酸及其衍生物在医药与化工领域的广阔前景。     

蓬勃发展的大环多胺化学

简要介绍了新型大环多胺及其衍生物的结构、性能、应用。重点综述了：①新型大环多胺及其金属配合物的合成；②大环多胺及其金属配合物对有机物和DNA的催化水解作用；③大环多胺阳离子脂质体的合成及在医学上的应用。并展望了大环多胺在生命科学、材料科学、环境科学、能源科学及医学上广阔的应用前景。     

Macrocyclic aminopyrimidines as multitarget CDK and VEGF-R inhibitors with potent antiproliferative activities

X-ray structures from CDK2-aminopyrimidine inhibitor complexes led to the idea to stabilize the active conformation of aminopyrimidine inhibitors by incorporating the recognition site into a macrocyclic framework. A modular synthesis approach that relies on a new late-stage macrocyclization protocol that enables fast and efficient synthesis of macrocyclic aminopyrimidines was developed. A set of structurally diverse derivatives was prepared. Macrocyclic aminopyrimidines were shown to be multitarget inhibitors of CDK1/2 and VEGF-RTKs. In addition, potent antiproliferative activities toward various human tumor cells and a human tumor xenograft model were demonstrated.     

Macrocyclic diamide based poly(vinyl chloride) membranes with a high lithium selectivity

Summary Macrocyclic diamides 2, 3 and 4 of 4,4,5,5-tetramethyl-3,6-dioxaoctanedioic acid were prepared. These compounds incorporated in poly (vinyl chloride) membranes show a remarkable selectivity for lithium ions.     

Evaluation of Gene Expression Knock-Down by Chemically and Structurally Modified Gapmer Antisense Oligonucleotides

We analyzed the effect of modified nucleotides within gapmer antisense oligonucleotides on RNase H mediated gene silencing. Additionally, short hairpins were introduced into antisense oligonucleotides as structural motifs, and their influence on biological and physicochemical properties of pre-structured gapmers was investigated for the first time. The results indicate that two LNA residues in specified positions of the gap flanking regions are sufficient and favorable for efficient knock-down of the β-actin gene. Furthermore, the introduction of other modified nucleotides, i. e. glycyl-amino-LNA−T, 2′-O-propagyluridine, polyamine functionalized uridine, and UNA, in specified positions, also increases the inhibition of β-actin expression. Importantly, the presence of hairpins within the gapmers improves their silencing properties.     

Adsorption of amino acid derivatives on calixarene carboxylic acid impregnated resins

Macrocyclic host molecules calixarene carboxylic acid derivatives are found to act as powerful extractants for biologically important amino compounds. A series of adsorbents were prepared from a methacrylate-based polymer Amberlite XAD-7 by impregnation with various calixarene derivatives, for adsorptive recovery of amino acid derivatives. The larger macrocycles calix[6]arene and calix[8]arene carboxylic acid derivatives were more effective for adsorption of amino acid derivatives on the impregnated resin than the calix[4]arene derivative. Since adsorption proceeds mainly via electrostatic interaction, the carboxylic acid groups introduced into the calixarene platform were important for adsorption of cationic amino acid derivatives. The adsorption selectivity for amino compounds using adsorbent impregnated with the calix[6]arene carboxylic acid derivative depends simply on the hydrophobicity of the adsorbates.     

7-(Dialkylamino)coumarin-4-yl]methyl-Caged Compounds as Ultrafast and Effective Long-Wavelength Phototriggers of 8-Bromo-Substituted Cyclic Nucleotides

[7-(Dimethylamino)coumarin-4-yl]methyl (DMACM) and [7-(diethylamino)coumarin-4-yl]methyl (DEACM) esters of 8-bromoadenosine 3',5'-cyclic monophosphate (8-Br-cAMP) and 8-bromoguanosine 3',5'-cyclic monophosphate (8-Br-cGMP) are described as novel caged compounds for 8-bromo-substituted cyclic nucleotides. Synthesis is accomplished by treatment of the free acids of the cyclic nucleotides with the corresponding 7(dialkylamino)-substituted 4(diazomethyl)coumarins. Irradiation of the DMACM- and DEACM-caged cyclic nucleotides with UV light stimulates the release of the cyclic nucleotides within roughly a nanosecond. The new caged compounds are resistant to hydrolysis in aqueous buffers and exhibit long-wavelength absorption properties with maxima at 400 nm, high extinction coefficients, and high quantum yields (0.15-0.31). Their favorable properties render these compounds the most efficient and rapid phototriggers of 8-bromo-substituted cyclic nucleotides known. The usefulness of the compounds for physiological studies under nondamaging light conditions was examined in HEK293 cells expressing the alpha subunit of the cyclic-nucleotide-gated (CNG) channel of cone photoreceptors (CNGA3) and of olfactory neurons (CNGA2) by using confocal laser scanning microscopy and the patch clamp technique.     

掺和改性聚醋酸乙烯溶剂型建筑粘合剂的研究

通过在均聚醋酸乙烯树脂中加入胺类、聚醚类、聚氨醚类和环氧树脂等各种掺和剂进行改性,使其使用时间有不同程度地提高,而粘合强度不下降。