STS教育与药物分析教学

通过对STS教育理念和药物分析的教学现状进行分析,以STS教育思想和当今社会对人才培养的要求为基础,对药物分析的教学改革进行探索。提出将STS教育引入药物分析课堂教学,增强学生的学习兴趣,提高教学质量,逐步培养学生各方面的能力;将STS教育引入药物分析实验教学,使实验内容生活化、趣味化,激发学生的学习兴趣,提高学生的科学素养;将STS教育引入课外学习,激发学生学习的兴趣,培养学生的科学精神和团队意识,增强学生的社会责任感,锻炼学生利用所学知识自主研究问题的能力。     

"新工科"背景下制药工程专业人才培养模式改革探索

未来新兴产业和新经济的快速发展对制药工程人才培养提出了新要求。在新工科背景下,结合我校制药工程专业的实际情况,在“以产出为导向、以学生发展为中心”的人才培养理念的指引下,根据社会需求实施专业动态调整战略,通过设计科学、可持续发展的专业课程体系,加强校企协同培养深度,培养学生的创新意识和实践能力,构建“互联网+”形势下的数据化教学模式,从而培养出社会符合度高的制药工程专业人才。     

实践教学推进制药工程专业的人才培养

为了推进制药工程专业的人才培养与社会需求的进一步衔接,本文根据实验教学、社会实践和就业实践教学等方面进行了探讨。以培养具有高专业素质的制药工程专业型人才为目标,以推进实践教学与社会需求无缝对接为导向,本文建立"以学生教育为主体,以能力培养为核心"的教学理念,探索出一套多层次、全方位的教学模式,旨在推进制药工程专业人才满足社会需求,更好地实现教学模式改革。     

基于STS教育理念的发酵工程课程教学改革探索

基于STS教育理念对发酵工程课程教学进行了改革探索,从教学内容、教学重点、教学手段、教学方法、实践教学、考核方式等方面介绍了STS教育理念的引入手段。改革旨在提高学生的理论基础和技术能力,加以在实践过程中的应用,服务于社会,促进科学技术与经济社会的可持续发展。通过改革实践取得了良好的教学效果。     

基于CDIO的制药工程专业药物化学课程的教学改革

为了培养出能满足当前医药工业发展需要的既懂药又懂工程的复合型创新人才,我们将CDIO工程教育理念引入到了制药工程专业核心课程药物化学的教学改革中,提高了课程教学质量,培养了学生创新能力、综合实践能力和团队协作能力。     

基于CDIO理念的制药专业有机化学教学改革

本文简要分析了目前工科有机化学教学过程中存在的棘手问题,通过将CDIO国际工程先进教育理念引入到制药工程专业的有机化学教学实践过程中,在教学内容和教学方式上进行改革创新,希望以此来提升工科有机化学教学效果,达到进一步提高制药工程专业学生综合素质的目的,为培养工程实践能力强的应用型技术人才提供新思路和新方法。     

基于CDIO模式的天然药物化学课程的教学改革

为适应现代制药工程教育发展潮流、培养高素质创新性人才,本文把CDIOT程教育模式引入到制药工程专业天然药物化学课程的教学体系中,以提高课程教学质量和效果,培养学生的综合实践能力、创新能力和团队合作能力。     

制药工艺学课程的CDIO工程教育模式教学改革

制药工程是一个较新的专业,制药工程本科专业培养的模式还不是很完善,为了提高教学质量,培养能满足当前医药工业发展需要的制药工程专门人才,本文把CDIO工程教育模式引入到制药工程专业的核心课程制药工艺学课程的教学改革中,以提高课程教学质量和效果,培养学生的综合实践能力、创新能力和团队合作能力。     

基于《国标》的制药工程专业人才培养目标研究

在分析了制药工程专业人才培养目标研究现状的基础上,对照《国标》,剖析了某高校所确立的制药工程专业人才培养目标。针对人才培养目标所存在的缺失和差距,提出了基于《国标》的制药工程专业人才培养目标正确定位的"培养理念更新、培养队伍提升、培养条件完善、培养体系优化、培养质量保障"五个原则。只要坚持这些原则,就可以很好地实现制药工程专业人才培养目标。     

制药工程专业《仪器分析》课程教学改革初探

《仪器分析》是制药工程专业一门重要的专业基础课程。根据制药工程专业培养方案及学科特点,从教学内容、教学方法、实践能力、考核方式几个方面入手,初步提出了《仪器分析》课程教学改革的思路:以培养学生理论知识、提高学生动手能力、适应医药行业需求为目标,培养学生综合能力,使其成为社会需要的制药工程专业人才。此思路有助于教学水平和质量的提高。     

Insect antifeedant properties of anthranoids from the genusVismia

Vismiones and ferruginins, representatives of a new class of lypophilic anthranoids from the genusVismia were found to inhibit feeding in larvae of species ofSpodoptera, Heliothis, and inLocusta migratoria.     

Direct observation of freeze-thaw instability of latex coatings via high pressure freezing and cryogenic SEM

Despite its industrial importance, the subject of freeze-thaw (F/T) stability of latex coatings has not been studied extensively. There is also a lack of fundamental understanding about the process and the mechanisms through which a coating becomes destabilized. High pressure (2100 bar) freezing fixes the state of water-suspended particles of polymer binder and inorganic pigments without the growth of ice crystals during freezing that produce artifacts in direct imaging scanning electron microscopy (SEM) of fracture surfaces of frozen coatings. We show that by incorporating copolymerizable functional monomers, it is possible to achieve F/T stability in polymer latexes and in low-VOC paints, as judged by the microstructures revealed by the cryogenic SEM technique. Particle coalescence as well as pigment segregation in F/T unstable systems are visualized. In order to achieve F/T stability in paints, latex particles must not flocculate and should provide protection to inorganic pigment and extender particles. Because of the unique capabilities of the cryogenic SEM, we are able to separate the effects of freezing and thawing, and study the influence of the rate of freezing and thawing on F/T stability. Destabilization can be caused by either freezing or thawing. A slow freezing process is more detrimental to F/T stability than a fast freezing process; the latter actually preserves suspension stability during freezing. Presented at the 82nd Annual Meeting of the Federation of Societies for Coatings Technology, October 27–29, 2004 in Chicago, IL. Tied for first place in The John A. Gordon Best Paper Competition.     

Ethanol and (−)-α-Pinene: Attractant Kairomones for Bark and Ambrosia Beetles in the Southeastern US

In 2002–2004, we examined the flight responses of 49 species of native and exotic bark and ambrosia beetles (Coleoptera: Scolytidae and Platypodidae) to traps baited with ethanol and/or (−)-α-pinene in the southeastern US. Eight field trials were conducted in mature pine stands in Alabama, Florida, Georgia, North Carolina, and South Carolina. Funnel traps baited with ethanol lures (release rate, about 0.6 g/day at 25–28°C) were attractive to ten species of ambrosia beetles (Ambrosiodmus tachygraphus, Anisandrus sayi, Dryoxylon onoharaensum, Monarthrum mali, Xyleborinus saxesenii, Xyleborus affinis, Xyleborus ferrugineus, Xylosandrus compactus, Xylosandrus crassiusculus, and Xylosandrus germanus) and two species of bark beetles (Cryptocarenus heveae and Hypothenemus sp.). Traps baited with (−)-α-pinene lures (release rate, 2–6 g/day at 25–28°C) were attractive to five bark beetle species (Dendroctonus terebrans, Hylastes porculus, Hylastes salebrosus, Hylastes tenuis, and Ips grandicollis) and one platypodid ambrosia beetle species (Myoplatypus flavicornis). Ethanol enhanced responses of some species (Xyleborus pubescens, H. porculus, H. salebrosus, H. tenuis, and Pityophthorus cariniceps) to traps baited with (−)-α-pinene in some locations. (−)-α-Pinene interrupted the response of some ambrosia beetle species to traps baited with ethanol, but only the response of D. onoharaensum was interrupted consistently at most locations. Of 23 species of ambrosia beetles captured in our field trials, nine were exotic and accounted for 70–97% of total catches of ambrosia beetles. Our results provide support for the continued use of separate traps baited with ethanol alone and ethanol with (−)-α-pinene to detect and monitor common bark and ambrosia beetles from the southeastern region of the US.     

Many Drugs of Abuse May Be Acutely Transformed to Dopamine,Norepinephrine and Epinephrine In Vivo

It is well established that a wide range of drugs of abuse acutely boost the signaling of the sympathetic nervous system and the hypothalamic–pituitary–adrenal (HPA) axis, where norepinephrine and epinephrine are major output molecules. This stimulatory effect is accompanied by such symptoms as elevated heart rate and blood pressure, more rapid breathing, increased body temperature and sweating, and pupillary dilation, as well as the intoxicating or euphoric subjective properties of the drug. While many drugs of abuse are thought to achieve their intoxicating effects by modulating the monoaminergic neurotransmitter systems (i.e., serotonin, norepinephrine, dopamine) by binding to these receptors or otherwise affecting their synaptic signaling, this paper puts forth the hypothesis that many of these drugs are actually acutely converted to catecholamines (dopamine, norepinephrine, epinephrine) in vivo, in addition to transformation to their known metabolites. In this manner, a range of stimulants, opioids, and psychedelics (as well as alcohol) may partially achieve their intoxicating properties, as well as side effects, due to this putative transformation to catecholamines. If this hypothesis is correct, it would alter our understanding of the basic biosynthetic pathways for generating these important signaling molecules, while also modifying our view of the neural substrates underlying substance abuse and dependence, including psychological stress-induced relapse. Importantly, there is a direct way to test the overarching hypothesis: administer (either centrally or peripherally) stable isotope versions of these drugs to model organisms such as rodents (or even to humans) and then use liquid chromatography-mass spectrometry to determine if the labeled drug is converted to labeled catecholamines in brain, blood plasma, or urine samples.     

Novel polyurethane coating technology through glycidyl carbamate chemistry

Glycidyl carbamate chemistry combines the excellent properties of polyurethanes with the crosslinking chemistry of epoxy resins. Glycidyl carbamate functional oligomers were synthesized by the reaction of polyfunctional isocyanate oligomers and glycidol. The oligomers were formulated into coatings with several amine functional crosslinkers at varying stoichiometric ratios and cured at different temperatures. Properties such as solvent resistance, hardness, and impact resistance were dependent on the composition and cure conditions. Most coatings had an excellent combination of properties. Studies were carried out to determine the kinetics of the curing reaction of the glycidyl carbamate functional oligomers with multifunctional and model amines. Detailed kinetic analysis of the curing reactions was also undertaken. The results indicated that the glycidyl carbamate functional group is more reactive than a glycidyl ether group. Presented at the 82nd Annual Meeting of the Federation of Societies for Coatings Technology, on October 27–29, 2004, in Chicago, IL.