纤维状甲基丙烯酸正丁酯／甲基丙烯酸β羟乙酯共聚树脂的性能

采用悬浮聚合法合成了甲基丙烯酸正丁酯、甲基丙烯酸β羟乙酯二元共聚树脂,并用冻胶纺丝技术制备了纤维状共聚物树脂.研究了甲基丙烯酸β羟乙酯含量对树脂饱和吸油率以及充分溶胀后树脂剩余率的影响,分别利用傅立叶变换红外光谱(FT-IR)和动态热机械分析仪(DMA)对树脂的化学结构和动态力学性能进行了分析和讨论.     

甲基丙烯酸正丁酯／甲基丙烯酸羟乙酯共聚树脂研究

采用悬浮聚合法合成了甲基丙烯酸正丁酯、甲基丙烯酸β羟乙酯二元共聚树脂，采用冻胶纺丝技术制备了纤维状共聚物树脂，研究了甲基丙烯酸β羟乙酯含量对树脂饱和吸油率、吸油速率以及充分溶胀后树脂剩余率的影响，分别利用傅立叶变换红外光谱（FTIR）和动态热机械分析仪（DMA）对树脂的化学结构和动态力学性能进行了分析和讨论，利用软件materials studio对甲基丙烯酸正丁酯、甲基丙烯酸β羟乙酯共聚过程中的物理缠结能力进行了模拟预测。     

RAFT聚合调控的聚甲基丙烯酸β-羟乙酯/纳米二氧化硅杂化材料的制备及性能

首先将偶氮类引发剂引到纳米二氧化硅的表面,然后以此为引发剂,以甲基丙烯酸叔丁酯基二硫代萘甲酸酯(TNPBE)为链转移剂(CTA),进行甲基丙烯酸β-羟乙酯的可逆加成-断裂链转移(RAFT)自由基聚合,制备了甲基丙烯酸β-羟乙酯/纳米二氧化硅(PHEMA/nano-SiO2)有机/无机杂化材料,并用红外光谱(FT-IR)、透射电镜(TEM)和热失重(TG)等方法对其结构和性能进行了表征与测试。研究结果表明,聚合物已经接枝到了纳米二氧化硅的表面,整个非均相体系中的聚合反应都是在链转移剂的作用下进行的,TG分析说明了此杂化材料的热稳定性良好。     

甲基丙烯酸氨基甲酸酯共聚物透明材料的研究

以六次甲基二异氰酸酯与二缩三乙二醇及甲基丙烯酸羟乙酯反应合成了带有活性端基的甲基丙烯酸氨基甲酸酯预聚体，进而与甲基丙烯酸甲酯进行共聚合反应，制备了一种新型的热固型透明材料。着重研究了材料的透光率、表面硬度、冲击强度、线性热膨胀系数以及热转变温度等性能，并用透射电子显微镜观察了材料的微观形态结构。     

NVP/HEMA/RMA共聚水凝胶溶胀性能研究

采用本体聚合法,制备了N-乙烯基吡咯烷酮(NVP)/甲基丙烯酸羟乙酯(HEMA)、NVP/HEMA/EMA(甲基丙烯酸乙酯)和NVP/HEMA/BMA(甲基丙烯酸丁酯)3种不同的共聚水凝胶材料,并用重量法和TG法研究了这3种不同组成水凝胶的溶胀性能.研究结果表明:加入疏水性单体甲基丙烯酸酯类,共聚水凝胶溶胀性能下降,由于EMA与HEMA结构相似,相容性好,其对溶胀性能的影响比BMA的影响小.     

共聚物水凝胶的合成及其溶胀性能研究

以过氧化二苯甲酰(BPO)为引发剂，合成了N-乙烯基吡咯烷酮(NVP)-甲基丙烯酸肛羟乙酯(HEMA)-甲基丙烯酸丁酯(BMA)共聚物水凝胶，可作为软性角膜接触镜材料。探讨了不同比例的NVP、HEMA、BMA对材料溶胀性能的影响。     

超临界CO_2中MCM-41-g-PHEMA介孔复合物的制备及性能

以甲基丙烯酸羟乙酯(HEMA)为单体,用乙烯基三乙氧基硅烷改性的介孔分子筛MCM-41为载体,偶氮二异丁腈为引发剂,在超临界二氧化碳中通过沉淀聚合,成功合成了聚甲基丙烯酸羟乙酯-二氧化硅介孔复合材料(MCM-41-gPHEMA)。考察了反应物配比、反应时间和反应压力对所制复合物形貌与产率的影响。对所合成的复合物进行红外光谱分析、比表面积、小角X射线衍射、扫描电镜、透射电镜、热重分析等表征。研究了复合物的溶胀性及在不同pH下对牛血清白蛋白(BSA)水溶液的吸附性能与吸附动力学。结果表明,MCM-41-g-PHEMA的孔径约为6.3nm,热稳定性明显提高,复合物对BSA的吸附动力学符合伪二级速率方程,最大吸附量为35mg/g。     

PLA嵌段的聚氨酯丙烯酸酯大单体的合成及聚合物的制备

利用乳酸与1,4-丁二醇(BDO)的缩聚反应,合成了PLA-BDO-PLA型嵌段预聚物,该预聚物与异佛尔酮-二异氰酸酯(IPDI)、甲基丙烯酸β羟乙酯(HEMA)反应,得到了聚氨酯丙烯酸酯大分子单体,将其固化制得聚氨酯材料.对材料的热行为(TG、DTG)及降解性能进行了表征,结果表明,该聚氨酯材料具有较好的热稳定性和降解性,在70 ℃水中静置24 h,其降解率可达9.55%;在室内环境下放置120 d后,材料的冲击强度下降26.3%.     

甲基丙烯酸树脂的合成及在负性光致抗蚀剂中的应用

以甲基丙烯酸(MAA)、甲基丙烯酸甲酯(MMA)、甲基丙烯酸羟乙酯(HEMA)和2-甲基-2-金刚烷基甲基丙烯酸酯(MAd MA)为单体,通过自由基聚合制备了不同MAd MA含量的共聚物PMMHM,再与甲基丙烯酸缩水甘油酯(GMA)反应制得光敏共聚物PMMHM-G。用傅里叶变换红外光谱、核磁共振氢谱、凝胶渗透色谱、差示扫描量热等表征了聚合物的结构与性能;以PMMHM-G为基体树脂配制了光致抗蚀剂,测试了抗蚀剂膜的硬度与附着力,并用扫描电子显微镜观测了光致抗蚀剂的分辨率。结果表明,随着MAd MA含量升高,共聚物的相对分子质量下降,玻璃化转变温度升高,树脂的耐碱性增强,光致抗蚀剂的硬度和附着力良好,分辨率达50μm。     

光敏甲基丙烯酸酯共聚物的合成及在负性光致抗蚀剂中的应用

以甲基丙烯酸(MAA)、甲基丙烯酸甲酯(MMA)、甲基丙烯酸羟乙酯(HEMA)和甲基丙烯酸苄基酯(BZMA)为原料,通过自由基聚合制备了聚甲基丙烯酸酯系列共聚物PMMHB,再用甲基丙烯酸缩水甘油酯(GMA)与PMMHB反应制得光敏共聚物PMMHB-G。用傅立叶红外光谱(FT-IR)、核磁共振氢谱(1H-NMR)、凝胶渗透色谱(GPC)、热重分析(TGA)和差示扫描量热(DSC)表征了聚合物的结构与性能,用光学显微镜和扫描电子显微镜(SEM)观测了光致抗蚀剂的耐酸性、微观线路及分辨率。结果表明,随共聚物组成中BZMA含量增加,其分子量(-Mn)和玻璃化温度(Tg)呈下降趋势,热分解温度(Td)提高,光致抗蚀剂的耐酸性随BZMA含量的增加而有所提高。由PMMHB-G制得光致抗蚀剂的图像线路清晰笔直,分辨率可达到40μm。     

可聚合阴离子表面活性剂微乳液聚合制备多孔高分子材料

利用易于合成的马来酸单十二醇酯钠盐为可聚合表面活性剂,以甲基丙烯酸羟乙酯为助表面活性剂,研究了甲基丙烯酸甲酯的微乳液聚合,制得了具有连续孔结构(即开孔结构)的高分子材料,孔的尺寸为100 nm至数微米,材料呈半透明至白色不透明状。用场发射扫描电镜对材料的微观结构进行表征;考察了表面活性剂浓度以及表面活性剂水溶液(水相)的含量对材料结构的影响。     

Synthesis of Chemically Cross-Linked Hydroxypropyl Methyl Cellulose Hydrogels and their Application in Controlled Release of 5-Amino Salicylic Acid

The objective of this study was to achieve the colon-specific delivery of an anti-ulcerative colitis drug using hydroxypropyl methyl cellulose (HPMC) hydrogels. HPMC hydrogels containing poly ethylene glycol (PEG) as cross-links have been prepared by reacting HPMC sodium salt with polyethylene glycol dichloride.

The effect of cross-linking agent on swelling behavior of HPMC-PEG hydrogels, were investigated. Swelling parameters such as equilibrium degree of swelling, swelling ratio and network parameter such as molecular mass between cross-links (M_c) were determined. The cross-linking concentrations were 0.5%, 1%, 1.5%, and 2% (based on weight of HPMC). The equilibrium swelling ratio (Q) of cross-linked HPMC hydrogels increases from 13.2 to 27.1 as the cross-linker percentage increases from 0.5% to 2%. 5-Aminosalicylic acid (5-ASA) was used as a model of an anti-inflammatory drug. Cross-linked HPMC hydrogels were found to be a promising drug delivery system for the drugs to be delivered to the colon.     

Synthesis of chemically cross-linked hydroxypropyl methyl cellulose hydrogels and their application in controlled release of 5-amino salicylic acid

The objective of this study was to achieve the colon-specific delivery of an anti-ulcerative colitis drug using hydroxypropyl methyl cellulose (HPMC) hydrogels. HPMC hydrogels containing poly ethylene glycol (PEG) as cross-links have been prepared by reacting HPMC sodium salt with polyethylene glycol dichloride.

The effect of cross-linking agent on swelling behavior of HPMC-PEG hydrogels, were investigated. Swelling parameters such as equilibrium degree of swelling, swelling ratio and network parameter such as molecular mass between cross-links (M_c) were determined. The cross-linking concentrations were 0.5%, 1%, 1.5%, and 2% (based on weight of HPMC). The equilibrium swelling ratio (Q) of cross-linked HPMC hydrogels increases from 13.2 to 27.1 as the cross-linker percentage increases from 0.5% to 2%. 5-Aminosalicylic acid (5-ASA) was used as a model of an anti-inflammatory drug. Cross-linked HPMC hydrogels were found to be a promising drug delivery system for the drugs to be delivered to the colon.     

单体组成对水凝胶接触镜材料结构的影响

以甲基丙烯酸羟乙酯(HEMA)、N乙烯吡咯烷酮(NVP)、丙烯酰胺(AM)、甲基丙烯酸甲酯(MMA)、甲基丙烯酸乙酯(EMA)或者甲基丙烯酸丁酯(BMA)为原料,采用本体共聚法制备水凝胶角膜接触镜材料。采用环境扫描电子显微镜(ESEM)研究各单体对水凝胶结构的影响,结果表明,在溶胀状态下,HEMA的均聚物水凝胶结构均匀,而HEMA与NVP共聚物水凝胶在微米层次上出现含水量不均;在脱水状态下,HEMA的均聚物以及HEMA与NVP共聚物表现出均匀的结构,HEMA与AM共聚物呈纤维状,而HEMA、NVP与MMA、EMA或者BMA共聚物均出现微米级塌缩。     

Effect of Low Molecule Polyamide and Nano-SiO2 on Properties of the Poly （MMA/BA/MAA）

Effects of low molecule polyamide （LMPA） and namometer SiO2 particles on the properties of the poly （MMA/ BA/MAA） adhesive for wearable and nonskid PVC （polyvinyl carbazole） materials were investigated. The experimental results show that the shear strength of poly （MMA/BA/MAA）/LMPA is increased, when the LMPA is added into poly （MMA/BA/MAA）. The optimum addition of LMPA is about 4 wt pct. By adding 3 wt pct nano-SiO2 into poly （MMA/BA/MAA）/LMPA adhesive, its properties such as the shear strength, thermal stability, wear resistance and sea waterproof resistance are increased too.     

苯基喹啉/丙烯酸酯共聚物的合成及荧光性能研究

合成了一种新型的喹啉衍生物单体-2-苯基喹啉-4-羧酸-丙烯酸-乙二醇二酯(PQFAED),并通过乳液聚合的方法制备了PQFAED和丙烯酸酯单体(MMA/MAA/BA)的共聚物-P(PQFAED/MMA/MAA/BA)。用IR、UV、GPC、TGA、PGC-MS及荧光光谱表征了单体及共聚物的结构,分析了硝基爆炸物(TNT、RDX及PETN)对该共聚物膜的荧光猝灭作用。结果表明,共聚物薄膜的最大发射波长为436nm,相对于单体的最大发射峰发生了36nm的红移;荧光"结构自猝灭效应",使PQFAED在相同生色团浓度下的荧光强度远低于其相应共聚物的荧光强度;共聚物薄膜对多硝基爆炸物有较好的荧光响应,可作为爆炸物检测的传感材料。     

Effect of Poly (Ethylene Glycol) Molecular Weight and Microparticle Size on Oral Insulin Delivery from P(MAA‐g‐EG) Microparticles

Five years of successful work in our lab have shown that graft copolymer networks of poly(methacrylic acid‐g‐ethylene) [P(MAA‐g‐EG)], are very promising candidates for oral drug delivery. In an acidic environment, these copolymers form interpolymer complexes, protecting the active agent from the harsh environment of the gastrointestinal tract. At high pH, these complexes dissociate, causing the polymer to swell and release the drug. Films of P(MAA‐g‐EG) with a monomer ratio of 1:1 (MAA:EG) were prepared by free radical solution UV‐polymerization, washed in order to remove the unreacted monomer, and crushed to form microparticles with different particle size distribution. Previous studies in our lab have focused on using polymer disks in their swelling studies. The swelling properties of polymer disks vs. crushed particles were investigated via equilibrium swelling experiments in this study. Another goal in this study is to compare different PEG chain length (MW‐400 and MW‐1000) and different particle size (150–212 microns, 90–150 microns and 25–90 microns) in their loading and release behavior. After 6 hours of exposing the polymer with the insulin solution we achieved approximately 90% of insulin loading.     

新型温敏网络半互穿多孔水凝胶的制备及其固定化酶的研究

以甲基丙烯酸羟乙酯(Hydroxyethyl methacrylate,HEMA)、N,N-二乙基丙烯酰胺(N,N-diethyl-Acrylamide,DEAAm)为原材料,通过自由基聚合反应合成一种温敏型多孔水凝胶,经接枝反应引入乙烯基,制得新型温敏网络半互穿多孔水凝胶。利用红外光谱(IR)、核磁共振碳谱(13 C NMR),结合扫描电镜(SEM)表征中间产物和最终产物。采用称重法研究最终产物的溶胀、去溶胀动力学,分析其溶胀性能和温度响应性。运用点击反应原理,以新型温敏网络半互穿多孔水凝胶固定肌酸激酶。釆用BCA(Bicinchoninic Acid)蛋白试剂盒法测定酶的固载量,pH法测定酶活。结果表明,新型温敏水凝胶合成成功,肌酸激酶的平均固载量为24.77mg·g~(-1),肌酸激酶的平均酶活为9.67U·g~(-1)。该新型温敏水凝胶对肌酸激酶具有良好的选择性和温度响应性,对实现肌酸激酶的高效利用具有很好的借鉴意义。     

N-乙烯吡咯烷酮/甲基丙烯酸-β-羟乙酯/甲基丙烯酸酯共聚物水凝胶中吸附水的状态

用过氧化二苯甲酰作为引发剂,合成了几种N-乙烯基吡咯烷酮(NVP)/甲基丙烯酸β-羟乙酯(HEMA)/甲基丙烯酸酯(RMA)共聚物水凝胶,用差热扫描量热法(DSC)和热重法(TG)对这些亲水凝胶中吸附水的状态进行了研究和比较.结果表明,水凝胶中水的状态大致可分为自由水、可冻结的结合水和非冻结的结合水.不同的RMA与NVP和HEMA共聚,溶胀度不同,其吸附水中不同状态水的含量也有所差异.